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  • Response: Value and Timing of Repeat Spirometry or FENO in Children With Asthma Remains Unclear

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    Accepted Manuscript (AM)
    Author(s)
    Fielding, Shona
    Pijnenburg, Marielle
    de Jongste, Johan C
    Pike, Katharine C
    Roberts, Graham
    Petsky, Helen
    Chang, Anne B
    Fritsch, Maria
    Frischer, Thomas
    Szefler, Stanley
    Gergen, Peter
    Vermeulen, Francoise
    Vael, Robin
    Turner, Steve
    Griffith University Author(s)
    Petsky, Helen
    Year published
    2019
    Metadata
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    Abstract
    To the Editor: We thank Drs Yawn and Kaplan for their interest and comments on our article in which we describe a secondary analysis of data from seven published trials where fractional exhaled nitric oxide (Feno) was used to guide asthma treatment in children.1 We believe that our results offer relevance to clinicians attempting to interpret repeated measurements of spirometry and Feno. To the best of our knowledge, our analysis is the first to: (1) compare the clinical outcomes following a change in FEV1 and Feno over time; (2) compare clinical outcomes following absolute vs percent change in Feno; and (3) describe clinical ...
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    To the Editor: We thank Drs Yawn and Kaplan for their interest and comments on our article in which we describe a secondary analysis of data from seven published trials where fractional exhaled nitric oxide (Feno) was used to guide asthma treatment in children.1 We believe that our results offer relevance to clinicians attempting to interpret repeated measurements of spirometry and Feno. To the best of our knowledge, our analysis is the first to: (1) compare the clinical outcomes following a change in FEV1 and Feno over time; (2) compare clinical outcomes following absolute vs percent change in Feno; and (3) describe clinical outcomes following changes in FEV1 that fall within the range of “normal.”
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    Journal Title
    Chest
    Volume
    155
    Issue
    6
    DOI
    https://doi.org/10.1016/j.chest.2019.03.016
    Copyright Statement
    © 2019 American College of Chest Physicians. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Clinical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Critical Care Medicine
    Respiratory System
    General & Internal Medicine
    Publication URI
    http://hdl.handle.net/10072/387067
    Collection
    • Journal articles

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