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dc.contributor.authorGonzalez-Miro, Majela
dc.contributor.authorChen, Shuxiong
dc.contributor.authorGonzaga, Zennia Jean
dc.contributor.authorEvert, Benjamin
dc.contributor.authorWibowo, David
dc.contributor.authorRehm, Bernd HA
dc.date.accessioned2019-09-12T01:25:31Z
dc.date.available2019-09-12T01:25:31Z
dc.date.issued2019
dc.identifier.issn1525-7797
dc.identifier.doi10.1021/acs.biomac.9b00509
dc.identifier.urihttp://hdl.handle.net/10072/387106
dc.description.abstractSpherical polyhydroxyalkanoate (PHA) inclusions are naturally self-assembled inside bacteria. These PHA beads are shell–core structures composed of a hydrophobic PHA core surrounded by proteins, such as PHA synthase (PhaC). PhaC is covalently attached and serves as an anchor protein for foreign protein vaccine candidate antigens. PHA beads displaying single and multiple antigens showed enhanced immunological properties when compared to respective soluble vaccines. This review highlights the unique design space of the PHA bead-based vaccines toward the development of safe and synthetic particulate vaccines. The PHA bead technology will be compared with chemically synthesized polyesters, such as polylactic acids, formulated to deliver vaccine antigens. The performance of PHA bead vaccine candidates to induce specific immune responses and protective immunity against bacterial and viral pathogens in animal trials will be summarized. We propose that the PHA bead technology offers a versatile vaccine platform for design and cost-effective manufacture of synthetic multivalent vaccines.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofpagefrom3213
dc.relation.ispartofpageto3232
dc.relation.ispartofjournalBiomacromolecules
dc.relation.ispartofvolume20
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode09
dc.titlePolyester as Antigen Carrier toward Particulate Vaccines
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGonzalez-Miro, M; Chen, S; Gonzaga, ZJ; Evert, B; Wibowo, D; Rehm, BHA, Polyester as Antigen Carrier toward Particulate Vaccines, Biomacromolecules, 2019
dc.date.updated2019-09-09T22:06:57Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyrightThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, © 2019 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.biomac.9b00509
gro.hasfulltextFull Text
gro.griffith.authorWibowo, David
gro.griffith.authorRehm, Bernd
gro.griffith.authorChen, Shuxiong
gro.griffith.authorGonzaga, Jean C.
gro.griffith.authorEvert, Ben J.


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