Retrospective cost-effectiveness of the 23-valent pneumococcal polysaccharide vaccination program in Australia

Abstract

The manuscript by Chen and colleagues [1] suggests that, based on retrospective Australian data, 23-valent pneumococcal polysaccharide vaccine (PPV23) has a worsening cost-effectiveness profile over time and is unlikely to be cost-effective unless it provides protection against non-invasive community acquired pneumococcal pneumonia (pneumococcal CAP). At an effectiveness of about 15% against pneumococcal CAP, the PPV23 program approached cost-effectiveness [1].

In their base case, Chen and colleagues assumed zero benefit from PPV23 against pneumococcal CAP. Such an assumption is inconsistent with recent studies which suggest PPV23 effectiveness against pneumococcal CAP is non-zero and could be as high as 50% (reviewed in Van Buynder and Booy [2]). Studies supportive of an effectiveness for PPV23 against vaccine-type (VT) pneumococcal CAP include: a Japanese prospective cohort study which found 33% VE (95% CI: 5.6–53.1%) against VT pneumococcal CAP in patients that had received at least one dose of PPV23 in the 5 years before [3]; a Spanish cohort study which found 48% (95% CI: 8–71%) VE against non-bacteraemic pneumococcal CAP in subjects vaccinated up to 5 years previously [4]; and a German meta-analytical review which allocated a VE against pneumococcal CAP of 64% (95% CI: 35–80%) out to 2.5 years in randomised clinical trials and of 48% (95% CI: 25–62%) in cohort studies followed out to 5 years [5]. Re-examination of the cost-effectiveness of the PPV23 program applying assumptions regarding effectiveness for PPV23 against VT pneumococcal CAP consistent with the literature described above would greatly enhance the contribution of this publication to public health decision making.