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dc.contributor.authorFu, Cheng-lin
dc.contributor.authorLiu, Ying
dc.contributor.authorLeng, Jing
dc.contributor.authorZhang, Jing
dc.contributor.authorHe, Yu-fang
dc.contributor.authorChen, Chen
dc.contributor.authorWang, Zi
dc.contributor.authorLi, Wei
dc.description.abstractThe root of Platycodon grandiflorus (Jacq.) A. DC. (P. grandiflorus), Platycodonis Radix, has been commonly applied to prevent and treat human diseases including bronchitis, asthma and excessive phlegm. Platycodin D (PD), one of the most important therapeutic components of P. grandiflorus, has been reported to possess protective effect against alcohol and carbon tetrachloride induced hepatotoxicity. In this study, we examined the protective efficacy of PD on acetaminophen (APAP)-induced liver injury and possible underlying mechanisms in C57BL/6J mice. Administration of PD prior to APAP intoxication significantly ameliorated the increase in serum transferases, interleukin 1β (IL-1β), IL-6, tumor necrosis factor alpha (TNF-α), and hepatic malondialdehyde (MDA) and the depletion of glutathione (GSH) in mice. PD pretreatment decreased the expression of heme oxygenase-1 (HO-1), cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-κB) in presence of APAP. Moreover, PD treatment noticeably reduced APAP-induced hepatocyte necrosis and apoptosis evidenced by evaluating physiological and histological hepatocyte changes in mice. Finally, PD pretreatment significantly diminished c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinases 1 and 2 (ERK1/2), and p38 phosphorylation induced by APAP. Collectively, PD pretreatment effectively protects hepatocytes against APAP-induced hepatotoxicity in mice through ameliorating oxidative stress, inflammatory response, and hepatocyte apoptosis.
dc.relation.ispartofjournalBiomedicine & Pharmacotherapy
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsMedicine, Research & Experimental
dc.subject.keywordsPharmacology & Pharmacy
dc.subject.keywordsResearch & Experimental Medicine
dc.titlePlatycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationFu, C-L; Liu, Y; Leng, J; Zhang, J; He, Y-F; Chen, C; Wang, Z; Li, W, Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice, Biomedicine & Pharmacotherapy, 2018, 107, pp. 867-877
gro.hasfulltextNo Full Text
gro.griffith.authorChen, Chen

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