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dc.contributor.authorZhang, Weizhe
dc.contributor.authorHou, Jingang
dc.contributor.authorYan, Xiaotong
dc.contributor.authorLeng, Jing
dc.contributor.authorLi, Rongyan
dc.contributor.authorZhang, Jing
dc.contributor.authorXing, Jingjing
dc.contributor.authorChen, Chen
dc.contributor.authorWang, Zi
dc.contributor.authorLi, Wei
dc.date.accessioned2019-09-09T23:50:46Z
dc.date.available2019-09-09T23:50:46Z
dc.date.issued2018
dc.identifier.issn2072-6643
dc.identifier.doi10.3390/nu10091328
dc.identifier.urihttp://hdl.handle.net/10072/387129
dc.description.abstractAlthough cisplatin is a potent chemotherapeutic agent against cancers, its clinical application is seriously limited by its severe side effects of nephrotoxicity. Previous studies reported that saponins isolated from the roots of Platycodon grandiflorum (PGS) exerted protective effects in various animal models of renal injury, with no confirmation on cisplatin-induced injury. This study was designed to investigate the protective effect of PGS (15 and 30 mg/kg) on cisplatin-induced kidney injury in mice. The levels of serum creatinine (CRE) and blood urea nitrogen (BUN), and renal histopathology demonstrated the protective effect of PGS against cisplatin-induced kidney injury. PGS exerted anti-inflammation effects via suppressing nuclear factor-kappa B (NF-κB) activation and alleviating the cisplatin-induced increase in inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) in kidney tissues. The expressions of phosphorylation of phosphatidylinositol 3-kinase/protein kinase B and its downstream apoptotic factors, such as Bcl-2 and caspase families were regulated by PGS in a dose-dependent manner. In conclusion, PGS exerted kidney protection effects against cisplatin-induced kidney injury by inhibiting the activation of NF-κB and regulating PI3K/Akt/apoptosis signaling pathways in mice.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofpagefrom1328-1
dc.relation.ispartofpageto1328-16
dc.relation.ispartofissue9
dc.relation.ispartofjournalNutrients
dc.relation.ispartofvolume10
dc.subject.fieldofresearchFood Sciences
dc.subject.fieldofresearchNutrition and Dietetics
dc.subject.fieldofresearchcode0908
dc.subject.fieldofresearchcode1111
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsNutrition & Dietetics
dc.subject.keywordsPlatycodon grandiflorum saponins
dc.subject.keywordscisplatin
dc.titlePlatycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-B-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationZhang, W; Hou, J; Yan, X; Leng, J; Li, R; Zhang, J; Xing, J; Chen, C; Wang, Z; Li, W, Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-B-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways, Nutrients, 2018, 10 (9), pp. 1328-1 - 1328-16
dcterms.dateAccepted2018-09-14
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-09-09T23:48:03Z
dc.description.versionPublished
gro.rights.copyright© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorChen, Chen


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