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dc.contributor.authorLeng, Jing
dc.contributor.authorWang, Zi
dc.contributor.authorFu, Cheng-lin
dc.contributor.authorZhang, Jing
dc.contributor.authorRen, Shen
dc.contributor.authorHu, Jun-nan
dc.contributor.authorJiang, Shuang
dc.contributor.authorWang, Ying-ping
dc.contributor.authorChen, Chen
dc.contributor.authorLi, Wei
dc.description.abstractAcute liver injury (ALI) induced by acetaminophen (APAP) overdose is the most common cause of drug-induced liver injury. Saponins from Platycodon grandiflorum (PGSs) ameliorate alcohol-induced hepatotoxicity and enhance human lung carcinoma cell death via AMPK signaling pathway. However, whether PGS could protect from APAP-induced ALI through AMPK activation and its downstream signals is still poorly elucidated. This work investigated the protective effect and the underlying mechanisms of PGS against APAP-induced liver toxicity in mouse. PGS was administered at 15 or 30 mg/kg i.g./day for 1 week before a single injection of APAP (250 mg/kg, i.p.) 1 hr after last treatment of PGS. Serum alanine/aspartate aminotransferases, liver tumor necrosis factor-α and interleukin-1β levels, liver malondialdehyde formation, liver glutathione depletion, cytochrome P450 E1, and 4-hydroxynonenal levels were measured to demonstrate the protective efficacy of PGS against APAP-induced ALI. Liver histological observation provided further evidence on PGS's protective effects. PGS treatment altered the phosphorylation of AMPK and PI3K/Akt, as well as the downstream signals including Bcl-2 family, caspase, and NF-κB in a dose-dependent manner. In conclusion, we demonstrate that PGS exhibits a significant liver protection against APAP-induced ALI, mainly through NF-κB and AMPK/PI3K/Akt signaling pathways.
dc.publisherWiley Blackwell
dc.relation.ispartofjournalPhytotherapy Research
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsChemistry, Medicinal
dc.subject.keywordsPharmacology & Pharmacy
dc.titleNF-kappa B and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationLeng, J; Wang, Z; Fu, C-L; Zhang, J; Ren, S; Hu, J-N; Jiang, S; Wang, Y-P; Chen, C; Li, W, NF-kappa B and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice, Phytotherapy Research, 2018, 32 (11), pp. 2235-2246
gro.hasfulltextNo Full Text
gro.griffith.authorChen, Chen

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