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dc.contributor.authorWang, YM
dc.contributor.authorCai, XL
dc.contributor.authorZhang, RT
dc.contributor.authorWang, Y
dc.contributor.authorMadsen, KH
dc.contributor.authorSørensen, TA
dc.contributor.authorMøller, A
dc.contributor.authorCheung, EFC
dc.contributor.authorChan, RCK
dc.description.abstractIntroduction: Investigating obsessive-compulsive symptoms in subclinical populations provides a useful framework for understanding the early development of obsessive-compulsive spectrum disorders. The present study aimed to apply searchlight classification analysis on resting-state functional magnetic resonance imaging data to identify potential brain markers in subclinical individuals with obsessive-compulsive symptoms. Methods: In this observational study, 40 college students with high obsessive-compulsive symptom scores and 40 with low obsessive-compulsive symptom scores were recruited from universities in China. We conducted searchlight classification and comparison analysis between the two groups based on Amplitude of Low Frequency Fluctuation (ALFF), fraction ALFF (fALFF) and resting-state functional connectivity using searchlight classification. Results: We found that the highest accuracy rate in differentiating between the two groups was 85.00%. Significant discriminating features included the ALFF of the left medial superior frontal gyrus and the functional connectivity between the right thalamus and the bilateral medial superior frontal gyrus, and the right putamen, as well as the functional connectivity between the left caudate and the right insula. Conclusions: These findings highlight the specific and distinguishing brain functional abnormalities associated with obsessive-compulsive symptoms.
dc.publisherTaylor & Francis
dc.publisher.placeUnited Kingdom
dc.relation.ispartofjournalCognitive Neuropsychiatry
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchPsychology and Cognitive Sciences
dc.subject.keywordsAmplitude of Low Frequency Fluctuation
dc.subject.keywordsObsessive-compulsive symptoms
dc.subject.keywordsfunctional connectivity
dc.titleSearchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationWang, YM; Cai, XL; Zhang, RT; Wang, Y; Madsen, KH; Sørensen, TA; Møller, A; Cheung, EFC; Chan, RCK, Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms, Cognitive Neuropsychiatry, 2019, pp. 1-13
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorChan, Raymond

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