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dc.contributor.authorWu, Yanheng
dc.contributor.authorChen, Mingshui
dc.contributor.authorWu, Peihong
dc.contributor.authorChen, Chen
dc.contributor.authorXu, Zhi Ping
dc.contributor.authorGu, Wenyi
dc.date.accessioned2019-09-10T04:34:47Z
dc.date.available2019-09-10T04:34:47Z
dc.date.issued2017
dc.identifier.issn1440-1681
dc.identifier.doi10.1111/1440-1681.12732
dc.identifier.urihttp://hdl.handle.net/10072/387182
dc.description.abstractHere we report the expression of programmed cell death ligand 1/2 (PD-L1/L2) in breast and colon cancer stem cells (CSCs). The stemness of these cells was confirmed by their surface markers. Using flow cytometry analysis we demonstrated that PD-L1 expression was higher in CSCs of both cancers compared to non-stem like cancer cells. Consistent with this, detection of cellular PD-L1 proteins by western blot assay also showed increased PD-L1 protein in CSCs. In contrast, only trace amounts of PD-L2 were detected in CSCs of both cancers. Our results suggest that breast and colon cancers may be sensitive to PD1/PD-L1 immunotherapy and thus warrant further investigations of CSC targeted PD1/PD-L1 therapy.
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley Blackwell
dc.relation.ispartofpagefrom602
dc.relation.ispartofpageto604
dc.relation.ispartofissue5
dc.relation.ispartofjournalClinical and Experimental Pharmacology and Physiology
dc.relation.ispartofvolume44
dc.subject.fieldofresearchPhysiology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchMedical Physiology
dc.subject.fieldofresearchcode0606
dc.subject.fieldofresearchcode1115
dc.subject.fieldofresearchcode1116
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsCLINICAL-SIGNIFICANCE
dc.titleIncreased PD-L1 expression in breast and colon cancer stem cells
dc.typeJournal article
dc.type.descriptionC2 - Articles (Other)
dcterms.bibliographicCitationWu, Y; Chen, M; Wu, P; Chen, C; Xu, ZP; Gu, W, Increased PD-L1 expression in breast and colon cancer stem cells, Clinical and Experimental Pharmacology and Physiology, 2017, 44 (5), pp. 602-604
dc.date.updated2019-09-10T04:33:03Z
gro.hasfulltextNo Full Text
gro.griffith.authorChen, Chen


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