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dc.contributor.authorChen, Xiaolin
dc.contributor.authorHuang, Lili
dc.contributor.authorTan, Hwee Y
dc.contributor.authorLi, Hongzhuo
dc.contributor.authorWan, Ying
dc.contributor.authorCowley, Michael
dc.contributor.authorVeldhuis, Johannes D
dc.contributor.authorChen, Chen
dc.date.accessioned2019-09-10T04:39:18Z
dc.date.available2019-09-10T04:39:18Z
dc.date.issued2017
dc.identifier.issn1470-1626
dc.identifier.doi10.1530/REP-16-0341
dc.identifier.urihttp://hdl.handle.net/10072/387184
dc.description.abstractDeletion of the melanocortin-4-receptor (Mc4r) gene in mice causes hyperphagia, followed by hyperinsulinemia, obesity and progressive infertility. Evidence shows that the number of developed corpora lutea is reduced in obese MC4R-knockout (MC4R KO) female mice, but the mechanism is unclear. The effect of hyperphagia and obesity by MC4R KO on pulsatile luteinizing hormone (LH) secretion and ovulation remains unknown. In MC4R KO mice and wild-type littermates (WT LM) during the diestrus period throughout different ages, we examined and monitored their metabolic status, pulsatile LH profiles, follicular morphology and the number of corpora lutea. MC4R KO mice were hyperphagic, obese, hyperglycemic, hyperinsulinemic and demonstrated insulin resistance and hepatic steatosis. Irregular estrous cycles and significant changes in the LH secretion profiles were observed in sexually matured 16- to 28-week MC4R KO mice, without any difference in testosterone levels. In addition, MC4R KO mice at 16 weeks of age had significantly fewer corpora lutea than same age WT LM mice. The ovary examinations of MC4R KO mice at 28 weeks of age showed predominantly antral and preovulatory follicles with no corpora lutea. These findings were consistent with the decrease in total, pulsatile, mass and basal LH releases in MC4R KO mice. The characteristics of hormone profiles in obese MC4R KO mice indicate that MC4R plays an important role in regulating LH release, ovulation and reproductive ability probably via hyperphagia-induced obesity. Further study of correlation between metabolic and reproductive regulatory hormones is warranted to dissect the pathological mechanism underlying obesity-induced infertility.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioScientifica
dc.relation.ispartofpagefrom267
dc.relation.ispartofpageto276
dc.relation.ispartofissue3
dc.relation.ispartofjournalReproduction
dc.relation.ispartofvolume153
dc.subject.fieldofresearchPhysiology
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchcode0606
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1114
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsDevelopmental Biology
dc.subject.keywordsReproductive Biology
dc.subject.keywordsLUTEINIZING-HORMONE SECRETION
dc.titleDeficient melanocortin-4 receptor causes abnormal reproductive neuroendocrine profile in female mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationChen, X; Huang, L; Tan, HY; Li, H; Wan, Y; Cowley, M; Veldhuis, JD; Chen, C, Deficient melanocortin-4 receptor causes abnormal reproductive neuroendocrine profile in female mice, Reproduction, 2017, 153 (3), pp. 267-276
dcterms.dateAccepted2016-12-05
dc.date.updated2019-09-10T04:37:58Z
gro.hasfulltextNo Full Text
gro.griffith.authorChen, Chen


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