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dc.contributor.authorLiu, L
dc.contributor.authorZhao, F
dc.contributor.authorLiu, W
dc.contributor.authorZhu, T
dc.contributor.authorZhang, JZH
dc.contributor.authorChen, C
dc.contributor.authorDai, Z
dc.contributor.authorPeng, H
dc.contributor.authorHuang, JL
dc.contributor.authorHu, Q
dc.contributor.authorBu, W
dc.contributor.authorTian, Y
dc.date.accessioned2019-09-10T04:46:34Z
dc.date.available2019-09-10T04:46:34Z
dc.date.issued2017
dc.identifier.issn1433-7851
dc.identifier.doi10.1002/anie.201705615
dc.identifier.urihttp://hdl.handle.net/10072/387189
dc.description.abstractHerein, we develop a novel method for designing electrochemical biosensors with both current and potential signal outputs for the simultaneous determination of two species in a living system. Oxygen (O2) and pH, simple and very important species, are employed as model molecules. By designing and synthesizing a new molecule, Hemin-aminoferrocene (Hemin-Fc), we create a single electrochemical biosensor for simultaneous detection and ratiometric quantification of O2 and pH in the brain. The reduction peak current of the hemin group increases with the concentration of O2 from 1.3 to 200.6 μm. Meanwhile, the peak potential positively shifts with decreasing pH from 8.0 to 5.5, resulting in the simultaneous determination of O2 and pH. The Fc group can serve as an internal reference for ratiometric biosensing because its current and potential signals remain almost constant with variations of O2 and pH. The developed biosensor has high temporal and spatial resolutions, as well as remarkable selectivity and accuracy, and is successfully applied in the real-time quantification of O2 and pH in the brain upon ischemia, as well as in tumor during cancer therapy.
dc.description.peerreviewedYesen_US
dc.languageengen_US
dc.publisherWiley
dc.relation.ispartofpagefrom10471
dc.relation.ispartofpageto10475
dc.relation.ispartofissue35
dc.relation.ispartofjournalAngewandte Chemie - International Edition
dc.relation.ispartofvolume56
dc.subject.fieldofresearchChemical Sciencesen_US
dc.subject.fieldofresearchcode03en_US
dc.subject.keywordsanalytical methodsen_US
dc.subject.keywordsbrain chemistryen_US
dc.subject.keywordscancer therapyen_US
dc.subject.keywordsoxygenen_US
dc.subject.keywordspHen_US
dc.titleAn Electrochemical Biosensor with Dual Signal Outputs: Toward Simultaneous Quantification of pH and O2 in the Brain upon Ischemia and in a Tumor during Cancer Starvation Therapy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationLiu, L; Zhao, F; Liu, W; Zhu, T; Zhang, JZH; Chen, C; Dai, Z; Peng, H; Huang, JL; Hu, Q; Bu, W; Tian, Y, An Electrochemical Biosensor with Dual Signal Outputs: Toward Simultaneous Quantification of pH and O2 in the Brain upon Ischemia and in a Tumor during Cancer Starvation Therapy, Angewandte Chemie - International Edition, 2017, 56 (35), pp. 10471-10475
dc.date.updated2019-09-10T04:45:28Z
gro.hasfulltextNo Full Text
gro.griffith.authorChen, Chen


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