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dc.contributor.authorYang, Jin-Kui
dc.contributor.authorWang, Ying-Ying
dc.contributor.authorLiu, Chang
dc.contributor.authorShi, Ting-Ting
dc.contributor.authorLu, Jing
dc.contributor.authorCao, Xi
dc.contributor.authorYang, Fang-Yuan
dc.contributor.authorFeng, Jian-Ping
dc.contributor.authorChen, Chen
dc.contributor.authorJi, Li-Nong
dc.contributor.authorXu, Aimin
dc.date.accessioned2019-09-10T04:50:21Z
dc.date.available2019-09-10T04:50:21Z
dc.date.issued2017
dc.identifier.issn0149-5992
dc.identifier.doi10.2337/dc16-1529
dc.identifier.urihttp://hdl.handle.net/10072/387191
dc.description.abstractOBJECTIVE: The predictive value of microalbuminuria (MAU) for kidney damage is limited in type 2 diabetes (T2D). We studied whether a urine proteome specific for sightthreatening proliferative diabetic retinopathy (PDR) is an indicator to predict chronic renal insufficiency (CRI) in patients with T2D. RESEARCH DESIGN AND METHODS: A shotgun urine proteomic analysis was performed in patients with MAU and PDR (case subjects) and in patients with MAU and a duration of T2D for >10 years but without any degree of retinopathy (control subjects). In the cohort study, 210 patients with T2D with an estimated glomerular filtration rate (eGFR) ≥80 mL/min/1.73m2 were followed for amedian of 5.3 years. Urine proteins specific for PDR were used for predicting CRI (eGFR <60 mL/min/1.73 m2). RESULTS: The top two urine proteins with the highest difference in ratio of case subjects to control subjects were haptoglobin (8.7 times; P < 0.0001) and a-2-macroglobulin (5.7 times; P < 0.0001). In the cohort study, patients with baseline urinary haptoglobin ≥20 ng/min (haptoglobinuria) had a higher incidence of CRI than those without (hazard ratio [95% CI] 3.27 [1.41-7.58]; P = 0.006). The overall CRI rate was 3.2% for patients without haptoglobinuria or MAU, 9.5% for those with MAU, and 13.3% for those with haptoglobinuria. The highest rate for CRI (22.4%) was in patients with both MAU and haptoglobinuria (P < 0.001). CONCLUSIONS: Urine haptoglobin, which is specific for PDR, is a novel biomarker and complement to urine albumin for predicting kidney damage in patients with T2D.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherAmeriican Diabetes Association
dc.relation.ispartofpagefrom253
dc.relation.ispartofpageto260
dc.relation.ispartofissue2
dc.relation.ispartofjournalDiabetes Care
dc.relation.ispartofvolume40
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode11
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsEndocrinology & Metabolism
dc.subject.keywordsHAPTOGLOBIN
dc.subject.keywordsRETINOPATHY
dc.titleUrine Proteome Specific for Eye Damage Can Predict Kidney Damage in Patients With Type 2 Diabetes: A Case-Control and a 5.3-Year Prospective Cohort Study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationYang, J-K; Wang, Y-Y; Liu, C; Shi, T-T; Lu, J; Cao, X; Yang, F-Y; Feng, J-P; Chen, C; Ji, L-N; Xu, A, Urine Proteome Specific for Eye Damage Can Predict Kidney Damage in Patients With Type 2 Diabetes: A Case-Control and a 5.3-Year Prospective Cohort Study, Diabetes Care, 2017, 40 (2), pp. 253-260
dcterms.dateAccepted2016-11-16
dc.date.updated2019-09-10T04:49:00Z
gro.hasfulltextNo Full Text
gro.griffith.authorChen, Chen


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