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  • Neuroendocrine Regulation of Growth Hormone Secretion

    Author(s)
    Steyn, Frederik J
    Tolle, Virginie
    Chen, Chen
    Epelbaum, Jacques
    Griffith University Author(s)
    Chen, Chen
    Year published
    2016
    Metadata
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    Abstract
    This article reviews the main findings that emerged in the intervening years since the previous volume on hormonal control of growth in the section on the endocrine system of the Handbook of Physiology concerning the intra- and extrahypothalamic neuronal networks connecting growth hormone releasing hormone (GHRH) and somatostatin hypophysiotropic neurons and the integration between regulators of food intake/metabolism and GH release. Among these findings, the discovery of ghrelin still raises many unanswered questions. One important event was the application of deconvolution analysis to the pulsatile patterns of GH secretion ...
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    This article reviews the main findings that emerged in the intervening years since the previous volume on hormonal control of growth in the section on the endocrine system of the Handbook of Physiology concerning the intra- and extrahypothalamic neuronal networks connecting growth hormone releasing hormone (GHRH) and somatostatin hypophysiotropic neurons and the integration between regulators of food intake/metabolism and GH release. Among these findings, the discovery of ghrelin still raises many unanswered questions. One important event was the application of deconvolution analysis to the pulsatile patterns of GH secretion in different mammalian species, including Man, according to gender, hormonal environment and ageing. Concerning this last phenomenon, a great body of evidence now supports the role of an attenuation of the GHRH/GH/Insulin-like growth factor-1 (IGF-1) axis in the control of mammalian aging.
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    Journal Title
    Comprehensive Physiology
    Volume
    6
    Issue
    2
    DOI
    https://doi.org/10.1002/cphy.c150002
    Subject
    Systems physiology
    Endocrinology
    Science & Technology
    Life Sciences & Biomedicine
    Physiology
    GH-RELEASING HORMONE
    RAT ANTERIOR-PITUITARY
    Publication URI
    http://hdl.handle.net/10072/387194
    Collection
    • Journal articles

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