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dc.contributor.authorSteyn, Frederik J
dc.contributor.authorTolle, Virginie
dc.contributor.authorChen, Chen
dc.contributor.authorEpelbaum, Jacques
dc.date.accessioned2019-09-10T05:09:03Z
dc.date.available2019-09-10T05:09:03Z
dc.date.issued2016
dc.identifier.issn2040-4603
dc.identifier.doi10.1002/cphy.c150002
dc.identifier.urihttp://hdl.handle.net/10072/387194
dc.description.abstractThis article reviews the main findings that emerged in the intervening years since the previous volume on hormonal control of growth in the section on the endocrine system of the Handbook of Physiology concerning the intra- and extrahypothalamic neuronal networks connecting growth hormone releasing hormone (GHRH) and somatostatin hypophysiotropic neurons and the integration between regulators of food intake/metabolism and GH release. Among these findings, the discovery of ghrelin still raises many unanswered questions. One important event was the application of deconvolution analysis to the pulsatile patterns of GH secretion in different mammalian species, including Man, according to gender, hormonal environment and ageing. Concerning this last phenomenon, a great body of evidence now supports the role of an attenuation of the GHRH/GH/Insulin-like growth factor-1 (IGF-1) axis in the control of mammalian aging.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley Blackwell
dc.relation.ispartofpagefrom687
dc.relation.ispartofpageto735
dc.relation.ispartofissue2
dc.relation.ispartofjournalComprehensive Physiology
dc.relation.ispartofvolume6
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPhysiology
dc.subject.keywordsGH-RELEASING HORMONE
dc.subject.keywordsRAT ANTERIOR-PITUITARY
dc.titleNeuroendocrine Regulation of Growth Hormone Secretion
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSteyn, FJ; Tolle, V; Chen, C; Epelbaum, J, Neuroendocrine Regulation of Growth Hormone Secretion, Comprehensive Physiology, 2016, 6 (2), pp. 687-735
dc.date.updated2019-09-10T05:08:08Z
gro.hasfulltextNo Full Text
gro.griffith.authorChen, Chen


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