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dc.contributor.authorLee-Archer, P
dc.contributor.authorMcBride, C
dc.contributor.authorPaterson, R
dc.contributor.authorReade, M
dc.contributor.authorRegli-Von Ungern-Sternberg, B
dc.contributor.authorLong, D
dc.date.accessioned2019-09-11T05:48:39Z
dc.date.available2019-09-11T05:48:39Z
dc.date.issued2018
dc.identifier.issn2044-6055en_US
dc.identifier.urihttp://hdl.handle.net/10072/387220
dc.description.abstractIntroduction: It has been reported that post-hospitalisation behaviour change (PHBC) occurs in over 50% of children undergoing a general anaesthetic and manifests as behaviours such as sleep and eating disorders, defiance of authority, nightmares, enuresis and temper tantrums. The effect is usually short-lived (2-4 weeks); however, in 5-10% of children, these behaviours can last up to 12 months. The risk factors for developing PHBC include underlying anxiety in the child or parent, a previous bad hospital experience, emergence delirium and preschool age. A recent meta-analysis of alpha-2 agonists (including dexmedetomidine) found that they effectively reduce the incidence of emergence delirium but none of the studies looked at longer term outcomes, such as PHBC. Methods and analysis: Two-year-old to seven-year-old children requiring general anaesthesia for common day-case procedures will be randomly assigned to one of three groups: a dexmedetomidine pre medication group, an intraoperative dexmedetomidine group and a control group. Baseline anxiety levels of the parent will be recorded and the anxiety of the child during induction of anaesthesia will also be recorded using validated tools. The primary outcome will be negative behaviours after hospitalisation and these will be measured using the Post Hospitalisation Behaviour Questionnaire for Ambulatory Surgery and the Strengths and Difficulties Questionnaire. These questionnaires will be administered by a blinded researcher at days 3, 14 and 28 post surgery. Ethics and dissemination: Ethics approval has been granted by the Children's Health Queensland human research ethics committee (HREC/15/QRCH/248) and the University of Queensland human research ethics office (#2016001715). Any amendments to this protocol will be submitted to the ethics committees for approval.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherBMJ Groupen_US
dc.publisher.placeUnited Kingdom
dc.publisher.urihttps://bmjopen.bmj.com/content/8/4/e019915en_US
dc.relation.ispartofpagefrome019915:1en_US
dc.relation.ispartofpagetoe019915:7en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalBMJ Openen_US
dc.relation.ispartofvolume8en_US
dc.subject.fieldofresearchClinical Sciencesen_US
dc.subject.fieldofresearchPublic Health and Health Servicesen_US
dc.subject.fieldofresearchOther Medical and Health Sciencesen_US
dc.subject.fieldofresearchcode1103en_US
dc.subject.fieldofresearchcode1117en_US
dc.subject.fieldofresearchcode1199en_US
dc.subject.keywordsclinical trialsen_US
dc.subject.keywordspaediatric anaesthesiaen_US
dc.titleDoes dexmedetomidine given as a premedication or intraoperatively reduce post-hospitalisation behaviour change in children? A study protocol for a randomised controlled trial in a tertiary paediatric hospitalen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationLee-Archer, P; McBride, C; Paterson, R; Reade, M; Regli-Von Ungern-Sternberg, B; Long, D, Does dexmedetomidine given as a premedication or intraoperatively reduce post-hospitalisation behaviour change in children? A study protocol for a randomised controlled trial in a tertiary paediatric hospital, BMJ Open, 2018, 8 (4), pp. e019915:1-e019915:7en_US
dcterms.licensehttps://creativecommons.org/licenses/by-nc/4.0/en_US
dc.date.updated2019-09-10T03:53:14Z
dc.description.versionPublisheden_US
gro.rights.copyright© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/en_US
gro.hasfulltextFull Text
gro.griffith.authorLong, Debbie A.


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