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dc.contributor.authorStefanidis, KB
dc.contributor.authorAskew, CD
dc.contributor.authorGreaves, K
dc.contributor.authorSummers, MJ
dc.date.accessioned2019-09-11T06:00:41Z
dc.date.available2019-09-11T06:00:41Z
dc.date.issued2018
dc.identifier.issn1040-7308
dc.identifier.doi10.1007/s11065-017-9359-z
dc.identifier.urihttp://hdl.handle.net/10072/387223
dc.description.abstractCardiovascular disease is associated with increased risk for cognitive decline and dementia, but it is unclear whether this risk varies across disease states or occurs in the absence of symptomatic stroke. To examine the evidence of increased risk for cognitive decline and dementia following non-stroke cardiovascular disease we conducted two independent meta-analyses in accordance with PRISMA guidelines. The first review examined cardiovascular diagnoses (atrial fibrillation, congestive heart failure, periphery artery disease and myocardial infarction) while the second review assessed the impact of atherosclerotic burden (as indicated by degree of stenosis, calcification score, plaque morphology or number of plaques). Studies eligible for review longitudinally assessed risk for clinically significant cognitive decline and/or dementia and excluded stroke and cognitive impairment at baseline. Summary statistics were computed via the inverse variance weighted method, utilising Cox Proportional Hazards data (Hazard Ratios, HR). Both atrial fibrillation (n = 5, HR = 1.26, 95% CI [1.12, 1.43]) and severe atherosclerosis (n = 4, HR = 1.59, 95% CI [1.12, 2.26]) emerged as significant risk factors for cognitive decline and/or dementia. A small set of studies reviewed, insufficient for meta-analysis, examining congestive heart failure, peripheral artery disease and myocardial infarction suggested that these conditions may also be associated with an increased risk of cognitive decline/dementia. In the absence of stroke, patients with atrial fibrillation or generalised atherosclerosis are at heightened risk for cognitive deterioration. Nonetheless, this paper highlights the need for methodologically rigorous and prospective investigation of the relationship between CVD and dementia.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherSpringer Nature
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto15
dc.relation.ispartofissue1
dc.relation.ispartofjournalNeuropsychology Review
dc.relation.ispartofvolume28
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1701
dc.subject.fieldofresearchcode1702
dc.subject.keywordsCardiovascular disease
dc.subject.keywordsCognitive decline
dc.subject.keywordsDementia
dc.subject.keywordsMeta-analysis
dc.titleThe Effect of Non-Stroke Cardiovascular Disease States on Risk for Cognitive Decline and Dementia: A Systematic and Meta-Analytic Review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationStefanidis, KB; Askew, CD; Greaves, K; Summers, MJ, The Effect of Non-Stroke Cardiovascular Disease States on Risk for Cognitive Decline and Dementia: A Systematic and Meta-Analytic Review, Neuropsychology Review, 2018, 28 (1), pp. 1-15
dcterms.dateAccepted2017-08-14
dc.date.updated2019-09-11T04:55:24Z
gro.hasfulltextNo Full Text
gro.griffith.authorGreaves, Kim
gro.griffith.authorSummers, Mathew


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