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dc.contributor.authorHuang, Y
dc.contributor.authorAlzahrani, NA
dc.contributor.authorFisher, OM
dc.contributor.authorChua, TC
dc.contributor.authorKozman, MA
dc.contributor.authorLiauw, W
dc.contributor.authorArrowaili, A
dc.contributor.authorValle, SJ
dc.contributor.authorMorris, DL
dc.date.accessioned2019-09-11T23:48:52Z
dc.date.available2019-09-11T23:48:52Z
dc.date.issued2019
dc.identifier.issn0002-9610
dc.identifier.doi10.1016/j.amjsurg.2018.12.037
dc.identifier.urihttp://hdl.handle.net/10072/387229
dc.description.abstractBackground: This study examines the impact of intraoperative macroscopic tumour consistency on short-term and long-term outcomes after cytoreductive surgery (CRS) with intraperitoneal chemotherapy (IPC) for appendiceal adenocarcinoma with peritoneal metastases. Methods: Macroscopic intraoperative tumour consistency was classified in three groups as soft (jelly-like geltatinous tumours), hard (hard tumour nodules without gelatinous features) and intermediate (both soft and hard features). In-hospital mortality, major morbidity, intensive care unit (ICU), high dependency unit (HDU) and total hospital stay, disease-free survival (DFS) and overall survival (OS) were compared. Results: The three groups had similar perioperative short-term outcomes. Patients with soft, intermediate and hard tumours revealed differences in OS (p < 0.001) and DFS (p = 0.03). Multivariable analysis revealed a shorter OS for patients with hard versus soft tumours (HR for hard tumours = 4.43, 95%CI 2.19–9.00). Conclusions: Intraoperative macroscopic tumour consistency may be used as a prognostic marker for survival in patients with appendiceal adenocarcinoma with peritoneal metastases.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom704
dc.relation.ispartofpageto712
dc.relation.ispartofissue4
dc.relation.ispartofjournalAmerican Journal of Surgery
dc.relation.ispartofvolume217
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.keywordsAppendix
dc.subject.keywordsConsistency
dc.subject.keywordsCytoreductive surgery
dc.subject.keywordsPeritoneal metastases
dc.subject.keywordsTumour characteristics
dc.titleIntraoperative macroscopic tumour consistency is associated with overall survival after cytoreductive surgery and intraperitoneal chemotherapy for appendiceal adenocarcinoma with peritoneal metastases: A retrospective observational study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHuang, Y; Alzahrani, NA; Fisher, OM; Chua, TC; Kozman, MA; Liauw, W; Arrowaili, A; Valle, SJ; Morris, DL, Intraoperative macroscopic tumour consistency is associated with overall survival after cytoreductive surgery and intraperitoneal chemotherapy for appendiceal adenocarcinoma with peritoneal metastases: A retrospective observational study, American Journal of Surgery, 2019, 217 (4), pp. 704-712
dcterms.dateAccepted2018-12-18
dc.date.updated2019-09-11T23:46:48Z
gro.hasfulltextNo Full Text
gro.griffith.authorChua, Terence


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