dc.contributor.author | Huang, Y | |
dc.contributor.author | Alzahrani, NA | |
dc.contributor.author | Fisher, OM | |
dc.contributor.author | Chua, TC | |
dc.contributor.author | Kozman, MA | |
dc.contributor.author | Liauw, W | |
dc.contributor.author | Arrowaili, A | |
dc.contributor.author | Valle, SJ | |
dc.contributor.author | Morris, DL | |
dc.date.accessioned | 2019-09-11T23:48:52Z | |
dc.date.available | 2019-09-11T23:48:52Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0002-9610 | |
dc.identifier.doi | 10.1016/j.amjsurg.2018.12.037 | |
dc.identifier.uri | http://hdl.handle.net/10072/387229 | |
dc.description.abstract | Background:
This study examines the impact of intraoperative macroscopic tumour consistency on short-term and long-term outcomes after cytoreductive surgery (CRS) with intraperitoneal chemotherapy (IPC) for appendiceal adenocarcinoma with peritoneal metastases.
Methods:
Macroscopic intraoperative tumour consistency was classified in three groups as soft (jelly-like geltatinous tumours), hard (hard tumour nodules without gelatinous features) and intermediate (both soft and hard features). In-hospital mortality, major morbidity, intensive care unit (ICU), high dependency unit (HDU) and total hospital stay, disease-free survival (DFS) and overall survival (OS) were compared.
Results:
The three groups had similar perioperative short-term outcomes. Patients with soft, intermediate and hard tumours revealed differences in OS (p < 0.001) and DFS (p = 0.03). Multivariable analysis revealed a shorter OS for patients with hard versus soft tumours (HR for hard tumours = 4.43, 95%CI 2.19–9.00).
Conclusions:
Intraoperative macroscopic tumour consistency may be used as a prognostic marker for survival in patients with appendiceal adenocarcinoma with peritoneal metastases. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 704 | |
dc.relation.ispartofpageto | 712 | |
dc.relation.ispartofissue | 4 | |
dc.relation.ispartofjournal | American Journal of Surgery | |
dc.relation.ispartofvolume | 217 | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.keywords | Appendix | |
dc.subject.keywords | Consistency | |
dc.subject.keywords | Cytoreductive surgery | |
dc.subject.keywords | Peritoneal metastases | |
dc.subject.keywords | Tumour characteristics | |
dc.title | Intraoperative macroscopic tumour consistency is associated with overall survival after cytoreductive surgery and intraperitoneal chemotherapy for appendiceal adenocarcinoma with peritoneal metastases: A retrospective observational study | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Huang, Y; Alzahrani, NA; Fisher, OM; Chua, TC; Kozman, MA; Liauw, W; Arrowaili, A; Valle, SJ; Morris, DL, Intraoperative macroscopic tumour consistency is associated with overall survival after cytoreductive surgery and intraperitoneal chemotherapy for appendiceal adenocarcinoma with peritoneal metastases: A retrospective observational study, American Journal of Surgery, 2019, 217 (4), pp. 704-712 | |
dcterms.dateAccepted | 2018-12-18 | |
dc.date.updated | 2019-09-11T23:46:48Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Chua, Terence | |