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dc.contributor.authorKong, L
dc.contributor.authorCui, H
dc.contributor.authorZhang, T
dc.contributor.authorWang, Y
dc.contributor.authorHuang, J
dc.contributor.authorZhu, Y
dc.contributor.authorTang, Y
dc.contributor.authorHerold, CJ
dc.contributor.authorSchröder, J
dc.contributor.authorCheung, EFC
dc.contributor.authorChan, RCK
dc.contributor.authorWang, J
dc.date.accessioned2019-09-12T04:31:21Z
dc.date.available2019-09-12T04:31:21Z
dc.date.issued2019
dc.identifier.issn2046-0252
dc.identifier.doi10.1002/pchj.258
dc.identifier.urihttp://hdl.handle.net/10072/387266
dc.description.abstractNeurological soft signs (NSSs), conventionally defined as subtle neurological abnormalities, are frequently found in individuals with schizophrenia. Many neuroimaging studies have also reported that NSSs are associated with grey matter changes in patients with schizophrenia at different stages of the illness. However, these findings may be confounded by the effect of antipsychotic medications, chronicity, and duration of untreated psychosis. Examining NSSs in individuals with ultra-high risk (UHR) for psychosis may help to identify the neuroanatomical substrates of NSSs related to the illness itself and to avoid these potential confounding effects. A sample of 21 individuals with UHR were included in the present study. NSSs were rated using the abridged version of the Cambridge Neurological Inventory. Grey matter volume was assessed using optimized voxel-based morphometry on images acquired by a high-resolution 3-T magnetic resonance imaging scanner. We found that higher NSS scores in individuals with UHR were associated with decreased grey matter volume at the superior and medial frontal cortex, the rectal cortex, the pre- and post-central cortex, the insula, the caudate, and the cerebellum. Our results suggest that these brain structural characteristics may represent the neuroanatomical substrate of NSSs in individuals with UHR. These findings contribute to the understanding of the intrinsic features of psychosis associated with NSSs and may provide insights into pre-schizophrenia pathophysiology.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofpagefrom252
dc.relation.ispartofpageto260
dc.relation.ispartofissue2
dc.relation.ispartofjournalPsyCh Journal
dc.relation.ispartofvolume8
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode5204
dc.subject.keywordsgrey matter volume
dc.subject.keywordsmagnetic resonance imaging
dc.subject.keywordsneurological soft signs
dc.subject.keywordsultra-high risk for psychosis
dc.subject.keywordsvoxel-based morphometry
dc.titleNeurological soft signs and grey matter abnormalities in individuals with ultra-high risk for psychosis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKong, L; Cui, H; Zhang, T; Wang, Y; Huang, J; Zhu, Y; Tang, Y; Herold, CJ; Schröder, J; Cheung, EFC; Chan, RCK; Wang, J, Neurological soft signs and grey matter abnormalities in individuals with ultra-high risk for psychosis, PsyCh Journal, 2019, 8 (2), pp. 252-260
dcterms.dateAccepted2018-10-16
dc.date.updated2019-09-12T04:29:03Z
gro.hasfulltextNo Full Text
gro.griffith.authorChan, Raymond


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