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dc.contributor.authorZhou, HY
dc.contributor.authorLi, Z
dc.contributor.authorXie, DJ
dc.contributor.authorXu, T
dc.contributor.authorCheung, EEF
dc.contributor.authorLi, H
dc.contributor.authorChan, RCK
dc.date.accessioned2019-09-12T04:37:20Z
dc.date.available2019-09-12T04:37:20Z
dc.date.issued2018
dc.identifier.issn2046-0260en_US
dc.identifier.doi10.1002/pchj.227en_US
dc.identifier.urihttp://hdl.handle.net/10072/387268
dc.description.abstractImpairments in spatial working memory (SWM) and set-shifting abilities have both been consistently observed in individuals with schizophrenia and are considered to be potential endophenotypes of this illness. However, an endophenotype needs to fulfill a set of stringent criteria, including heritability. This study examined the heritability of these two functions in a healthy Chinese twin sample. Forty-five pairs of monozygotic (MZ) twins and 35 pairs of dizygotic (DZ) twins completed the SWM task and the Intra-Extra Dimensional Set-Shifting (IED) task of the Cambridge Neuropsychological Test Automated Battery (CANTAB). We found a moderate heritability for SWM, of which the familial/genetic factors accounted for 33% of the total variance. However, we failed to find any significant heritability for set-shifting ability, of which the specific environmental factor explained most of the variance (85%). The preliminary findings from this small healthy Chinese twin sample suggest that SWM is heritable, whereas the set-shifting ability may reflect “extra-genetic” influences.en_US
dc.description.peerreviewedYesen_US
dc.languageengen_US
dc.publisherWileyen_US
dc.relation.ispartofpagefrom144en_US
dc.relation.ispartofpageto151en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalPsyCh Journalen_US
dc.relation.ispartofvolume7en_US
dc.subject.fieldofresearchPsychologyen_US
dc.subject.fieldofresearchCognitive Sciencesen_US
dc.subject.fieldofresearchcode1701en_US
dc.subject.fieldofresearchcode1702en_US
dc.subject.keywordsendophenotypeen_US
dc.subject.keywordsheritabilityen_US
dc.subject.keywordsset-shiftingen_US
dc.subject.keywordsspatial working memoryen_US
dc.subject.keywordstwins designen_US
dc.titleHeritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary studyen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationZhou, HY; Li, Z; Xie, DJ; Xu, T; Cheung, EEF; Li, H; Chan, RCK, Heritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary study, PsyCh Journal, 2018, 7 (3), pp. 144-151en_US
dcterms.dateAccepted2018-07-02
dc.date.updated2019-09-12T04:35:31Z
gro.hasfulltextNo Full Text
gro.griffith.authorChan, Raymond


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