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dc.contributor.authorShan, S
dc.contributor.authorFang, L
dc.contributor.authorHuang, J
dc.contributor.authorChan, RCK
dc.contributor.authorJia, G
dc.contributor.authorWan, W
dc.date.accessioned2019-09-12T05:04:02Z
dc.date.available2019-09-12T05:04:02Z
dc.date.issued2017
dc.identifier.issn1386-341X
dc.identifier.doi10.1007/s11102-017-0831-9
dc.identifier.urihttp://hdl.handle.net/10072/387277
dc.description.abstractPurpose: This study aimed to explore different aspects of executive function in patients with acromegaly and investigate the cause of dysexecutive syndrome in these patients. Methods: We conducted five typical executive function tests (Stroop test, verbal fluency [VF] test, Hayling Sentence Completion Test [HSCT], N-back test, and Sustained Attention to Response Task [SART]) on 42 acromegalic patients and 42 strictly matched healthy controls. Comparative analyses were conducted for five major executive function domains. The Dysexecutive Questionnaire (DEX) was used to assess patients’ subjective feelings about their executive function. All patients underwent a magnetic resonance imaging (MRI) examination and a blood test to determine their pituitary hormone levels before the tests were performed. Results: The patients exhibited worse results on the Stroop test, VF test, HSCT and N-back test compared to the healthy control group. Moreover, part B of the HSCT and the N-back test performance were negatively correlated with IGF-1 concentrations, and the duration of the disease was significantly associated with the Stroop color task results. Conclusions: Acromegalic patients were severely impaired in semantic inhibition, executive processing, working memory and executive inhibition, and they have realized a portion of these deficits. A high level of IGF-1, disease duration may contribute to the impairment of specific aspects of executive function.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.ispartofpagefrom661
dc.relation.ispartofpageto667
dc.relation.ispartofissue6
dc.relation.ispartofjournalPituitary
dc.relation.ispartofvolume20
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.subject.keywordsAcromegaly
dc.subject.keywordsDisease duration
dc.subject.keywordsDysexecutive function
dc.subject.keywordsIGF-1
dc.titleEvidence of dysexecutive syndrome in patients with acromegaly
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationShan, S; Fang, L; Huang, J; Chan, RCK; Jia, G; Wan, W, Evidence of dysexecutive syndrome in patients with acromegaly, Pituitary, 2017, 20 (6), pp. 661-667
dc.date.updated2019-09-12T05:00:43Z
gro.hasfulltextNo Full Text
gro.griffith.authorChan, Raymond


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