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dc.contributor.authorWhitman, M
dc.contributor.authorJenkins, C
dc.contributor.authorSabapathy, S
dc.contributor.authorAdams, L
dc.date.accessioned2019-09-13T01:15:09Z
dc.date.available2019-09-13T01:15:09Z
dc.date.issued2019
dc.identifier.issn0001-5385
dc.identifier.doi10.1080/00015385.2019.1653566
dc.identifier.urihttp://hdl.handle.net/10072/387292
dc.description.abstractBackground: Dobutamine stress echocardiography (DSE) is a commonly used diagnostic stress test for the assessment of various cardiac pathologies on patients unable to perform exercise. Unlike exercise, there is no reliable subjective termination end-point such as fatigue to rely on. Consequently, DSE’s are often concluded at a predetermined age predicted maximal heart rate (APMHR) such as 85%. The aim of this study was to assess if APMHR, heart rate reserve (HRR) and the maximum rate pressure product (MRPP) are valid measures of future cardiovascular (CV) events in otherwise negative DSEs. Methods: Following exclusions, receiver operating curve (ROC) analyses were performed on 652 patients using CV events during the follow-up period (4.2 ± 1.8 years) as the outcome variable. Results: ROC analyses failed to produce a statistically valid model for MRPP (p =.227, area under curve (AUC)=0.55) with a sensitivity and specificity of 21.1% and 91.9%, respectively at the optimal cut point (14948 MRPP). To the contrary, APMHR produced a sensitivity and specificity of 74.7% and 60.9%, respectively (p <.0001, AUC = 0.715). HRR however, with a sensitivity and specificity of 67.4% and 68.2% (p <.0001, AUC = 0.718) was the only predictor of CV events following Cox analysis (p <.0001). Conclusions: This study demonstrates MRPP as a poor measure of CV event prediction during DSE. While an APMHR of 89.3% demonstrated a statistically valid model, HRR was the only predictor of CV events in otherwise negative DSEs.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherTaylor & Francis
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto8
dc.relation.ispartofjournalActa Cardiologica
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchcode3201
dc.subject.keywordsRate pressure product
dc.subject.keywordsage predicted maximal heart rate
dc.subject.keywordscardiovascular events
dc.subject.keywordsdobutamine stress echocardiography
dc.subject.keywordsheart rate reserve
dc.titleComparison of heart rate reserve, age predicted maximum heart rate and rate pressure product as predictors of future cardiovascular events following a negative dobutamine stress echocardiogram
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationWhitman, M; Jenkins, C; Sabapathy, S; Adams, L, Comparison of heart rate reserve, age predicted maximum heart rate and rate pressure product as predictors of future cardiovascular events following a negative dobutamine stress echocardiogram, Acta Cardiologica, 2019, pp. 1-8
dc.date.updated2019-09-12T22:30:05Z
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version
gro.hasfulltextNo Full Text
gro.griffith.authorSabapathy, Surendran


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