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dc.contributor.authorHu, Ping
dc.contributor.authorWang, Rui
dc.contributor.authorZhou, Lei
dc.contributor.authorChen, Lei
dc.contributor.authorWu, Qingsheng
dc.contributor.authorHan, Ming-Yong
dc.contributor.authorEl-Toni, Ahmed Mohamed
dc.contributor.authorZhao, Dongyuan
dc.contributor.authorZhang, Fan
dc.date.accessioned2019-09-16T06:20:52Z
dc.date.available2019-09-16T06:20:52Z
dc.date.issued2017
dc.identifier.issn0003-2700
dc.identifier.doi10.1021/acs.analchem.6b04548
dc.identifier.urihttp://hdl.handle.net/10072/387356
dc.description.abstractAs a light-activated noninvasive cancer treatment paradigm, photodynamic therapy (PDT) has attracted extensive attention because of its high treatment efficacy and low side effects. Especially, spatiotemporal control of singlet oxygen (1O2) release is highly desirable for realizing on-demand PDT, which, however, still remains a huge challenge. To address this issue, a novel switchable near-infrared (NIR)-responsive upconversion nanoprobe has been designed and successfully applied for controlled PDT that can be optically activated by tumor-associated disruption of labile Zn2+ (denoted as Zn2+ hereafter) homeostasis stimuli. Upon NIR irradiation, this theranostic probe can not only quantitatively detect the intracellular endogenous Zn2+ in situ but also selectively generate a great deal of cytotoxic reactive oxygen species (ROS) for efficiently killing breast cancer cells under the activation of excessive endogenous Zn2+, so as to maximally avoid adverse damage to normal cells. This study aims to propose a new tumor-specific PDT paradigm and, more importantly, provide a new avenue of thought for efficient cancer theranostics based on our designed highly sensitive upconversion nanoprobes. (Figure Presented).
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS Publications)
dc.relation.ispartofpagefrom3492
dc.relation.ispartofpageto3500
dc.relation.ispartofissue6
dc.relation.ispartofjournalAnalytical Chemistry
dc.relation.ispartofvolume89
dc.subject.fieldofresearchAnalytical chemistry
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchcode3401
dc.subject.fieldofresearchcode3499
dc.subject.keywordsScience & Technology
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsChemistry, Analytical
dc.subject.keywordsChemistry
dc.subject.keywordsSINGLET OXYGEN GENERATION
dc.titleNear-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+ Detection and Selective On-Demand Photodynamic Therapy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHu, P; Wang, R; Zhou, L; Chen, L; Wu, Q; Han, M-Y; El-Toni, AM; Zhao, D; Zhang, F, Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+ Detection and Selective On-Demand Photodynamic Therapy, Analytical Chemistry, 2017, 89 (6), pp. 3492-3500
dc.date.updated2019-09-16T06:19:20Z
gro.hasfulltextNo Full Text
gro.griffith.authorZhao, Dongyuan


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