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dc.contributor.authorYang, Wei-fa
dc.contributor.authorChoi, Wing Shan
dc.contributor.authorLeung, Yiu Yan
dc.contributor.authorCurtin, Justin Paul
dc.contributor.authorDu, Ruxu
dc.contributor.authorZhang, Chun-yu
dc.contributor.authorChen, Xian-shuai
dc.contributor.authorSu, Yu-xiong
dc.date.accessioned2019-09-16T06:53:25Z
dc.date.available2019-09-16T06:53:25Z
dc.date.issued2018
dc.identifier.issn1368-8375
dc.identifier.doi10.1016/j.oraloncology.2018.01.005
dc.identifier.urihttp://hdl.handle.net/10072/387367
dc.description.abstractBACKGROUND: Surgical plates have been extensively used in head and neck reconstruction and conventional plates are mass-produced with universal configurations. To overcome disadvantages of conventional surgical plates, we have been exploring patient-specific surgical plates using the three-dimensional (3D) printing technology. We hypothesized that the application of 3D-printed patient-specific surgical plates in head and neck reconstruction is feasible, safe and precise. METHODS: We are conducting a prospective clinical trial to assess the feasibility, safety and accuracy of applying 3D-printed patient-specific surgical plates in head and neck reconstruction. The primary endpoint was the intraoperative success rate. Secondary endpoints included the incidence and severity of postoperative adverse events within six months postoperatively. The accuracy of surgical outcomes was also explored by comparing the planned and final positions of the maxilla, mandible and grafted bone segments. RESULTS: From December 2016 to October 2017, ten patients were enrolled and underwent head and neck reconstruction using 3D-printed patient-specific surgical plates. The patient-specific surgical plates adapted to bone surface precisely and no plate-bending was performed. The intraoperative success rate was 100%. The average follow-up period was 6.5 months. No major adverse events were observed. The mean absolute distance deviation of integral mandible or maxilla was 1.40 ± 0.63 mm, which showed a high accuracy of reconstruction. CONCLUSIONS: The 3D printing of patient-specific surgical plates could be effective in head and neck reconstruction. Surgical procedures were simplified. The precise jaw reconstruction was achieved with high accuracy. Long-term results with a larger sample size are warranted to support a final conclusion. The study protocol has been registered in ClinicalTrials.gov with a No. of NCT03057223.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom31
dc.relation.ispartofpageto36
dc.relation.ispartofjournalOral Oncology
dc.relation.ispartofvolume78
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode1105
dc.subject.fieldofresearchcode1112
dc.subject.fieldofresearchcode1117
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsDentistry, Oral Surgery & Medicine
dc.subject.keywordsThree-dimensional printing
dc.titleThree-dimensional printing of patient-specific surgical plates in head and neck reconstruction: A prospective pilot study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationYang, W-F; Choi, WS; Leung, YY; Curtin, JP; Du, R; Zhang, C-Y; Chen, X-S; Su, Y-X, Three-dimensional printing of patient-specific surgical plates in head and neck reconstruction: A prospective pilot study, Oral Oncology, 2018, 78, pp. 31-36
dcterms.dateAccepted2018-01-09
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2019-09-16T06:50:26Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorCurtin, Justin


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