Commentary on "High incidence of persistent sub-therapeutic levels of most common AEDs in children with epilepsy receiving polypharmacy"
Author(s)
Beran, Roy G
Griffith University Author(s)
Year published
2018
Metadata
Show full item recordAbstract
The paper by Czornyj et al. accepts the hypothesis that non-compliance/non-adherence to a therapeutic regimen may well explain the presence of low antiepileptic medication (AEM) blood levels in ambulatory patients but does not accept this as an explanation for low levels in patients who are admitted to hospital, The paper explores blood levels of the most commonly used AEMs, namely phenytoin (PHT), phenobarbitone (PHB), valproate (VPA) and carbamazepine (CBZ). It demonstrated higher rates of low PHT levels than was the case for PHB, VPA or CBZ.The paper by Czornyj et al. accepts the hypothesis that non-compliance/non-adherence to a therapeutic regimen may well explain the presence of low antiepileptic medication (AEM) blood levels in ambulatory patients but does not accept this as an explanation for low levels in patients who are admitted to hospital, The paper explores blood levels of the most commonly used AEMs, namely phenytoin (PHT), phenobarbitone (PHB), valproate (VPA) and carbamazepine (CBZ). It demonstrated higher rates of low PHT levels than was the case for PHB, VPA or CBZ.
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Journal Title
Epilepsy Research
Volume
148
Subject
Clinical sciences
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences & Neurology