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dc.contributor.authorLeumi, Steve
dc.contributor.authorBigna, Jean Joel
dc.contributor.authorAmougou, Marie A
dc.contributor.authorAminde, Leopold N
dc.contributor.authorNyaga, Ulrich Flore
dc.contributor.authorNoubiap, Jean Jacques
dc.date.accessioned2019-09-18T00:06:35Z
dc.date.available2019-09-18T00:06:35Z
dc.date.issued2018
dc.identifier.issn2046-4053
dc.identifier.doi10.1186/s13643-018-0815-5
dc.identifier.urihttp://hdl.handle.net/10072/387452
dc.description.abstractBACKGROUND: Hepatitis B causes death mainly due to liver disease worldwide. Human immunodeficiency virus increases the pathological effect of hepatitis viruses and potentiates re-activation of latent hepatitis infections as a result of reduced immunity. Because of the same modes of transmission shared by the two infections, HBV represents an important cause of co-morbidity and mortality among people living with HIV; hence, the aim of this review is to determine the prevalence of HBV among people living with HIV. METHODS: This systematic review and meta-analysis will include cross-sectional, case-control, and cohort studies of patients positive for HBV and HIV irrespective of their countries. All pertinent articles published on hepatitis B in people living with HIV from January 1, 1990, to July 31, 2017, without any language restriction will be searched in PubMed/MEDLINE, Global Index Medicus Web of Science, and Excerpta Medica Database. Two review authors will independently assess the relevance of all titles and abstracts identified from the electronic searches. The study-specific estimates will be pooled through a random-effects meta-analysis model to obtain an overall summary estimate of the prevalence of HBV across studies. We will assess statistical heterogeneity and pool clinically homogeneous studies. On the other hand, we will evaluate statistical heterogeneity by the chi-squared test on Cochrane's Q statistic. Symmetry of funnel plots and Egger's test will be used to detect the presence of publication and selective reporting bias. In the case of publication bias, we will report estimates after adjustment on publication bias using the trim-and-fill method. We will assess inter-rater agreement between investigators for study inclusion, data extraction, and methodological quality assessment using Kappa Cohen's coefficient. This protocol will comply with the guidelines for meta-analyses and systematic reviews of Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). DISCUSSION: To our knowledge, this is the first systematic review and meta-analysis protocol to report the prevalence of HBV in people living with HIV. We believe its outcomes will be of utility in providing insights on the characteristics of HBV epidemic in people living with HIV, and draw more attention of public health services to this association. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42017073124.
dc.languageEnglish
dc.publisherBioMed Central Ltd.
dc.relation.ispartofpagefrom146:1
dc.relation.ispartofpageto146:4
dc.relation.ispartofissue1
dc.relation.ispartofjournalSystematic Reviews
dc.relation.ispartofvolume7
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode11
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsMedicine, General & Internal
dc.subject.keywordsGeneral & Internal Medicine
dc.subject.keywordsHepatitis B
dc.titleGlobal, regional, and national prevalence of hepatitis B infection in the general and key populations living with HIV: a systematic review and meta-analysis protocol
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationLeumi, S; Bigna, JJ; Amougou, MA; Aminde, LN; Nyaga, UF; Noubiap, JJ, Global, regional, and national prevalence of hepatitis B infection in the general and key populations living with HIV: a systematic review and meta-analysis protocol, Systematic Reviews, 2018, 7 (1), pp. 146:1-146:4
dcterms.dateAccepted2018-09-13
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-09-17T04:17:23Z
dc.description.versionPublished
gro.rights.copyright© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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gro.griffith.authorAminde, Leopold N.


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