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dc.contributor.authorBernaitis, Nijole
dc.contributor.authorClark, Gemma
dc.contributor.authorKohja, Sarah
dc.contributor.authorLeong, Stephanie
dc.contributor.authorAnoopkumar-Dukie, Shailendra
dc.date.accessioned2019-09-19T22:42:47Z
dc.date.available2019-09-19T22:42:47Z
dc.date.issued2019
dc.identifier.issn2077-0383
dc.identifier.doi10.3390/jcm8060882
dc.identifier.urihttp://hdl.handle.net/10072/387538
dc.description.abstractBackground: Warfarin requires regular monitoring with the time in therapeutic range (TTR), a common indicator of control and TTR > 70% is indicative of efficient anticoagulation. The SAMe-TT2R2 (sex, age, medical history, treatment, tobacco use, race) model has been utilised as a predictor of warfarin control, with a score ≥ 2 indicative of poor control. However, it has been suggested that race may be over-represented in this model. To date, no Australian studies have applied this model, possibly because race is not routinely recorded. Therefore, the aim of this study was to apply the SAMe-TT2R2 model in an Australian population on warfarin managed by both a warfarin care program (WCP) and general practitioner (GP). Methods: Retrospective data was collected for patients receiving warfarin via a WCP in Queensland and whilst being managed by a GP. Patient data was used to calculate the SAMe-TT2R2 score and the TTR for each patient. Mean TTR was used for analysis and comparison with the categorised SAMe-TT2R2 score. Results: Of the 3911 patients managed by a WCP, there was a significantly lower mean TTR for patients with a SAMe-TT2R2 score ≥ 2 compared to 0–1 (78.6 ± 10.7% vs. 80.9 ± 9.5%, p < 0.0001). Of these patients, 200 were analysed whilst managed by a GP and the categorised SAMe-TT2R2 score did not result in a statistically different mean TTR (69.3 ± 16.3% with 0–1 vs. 63.6 ± 15.0% with ≥2, p = 0.089), but a score ≥2 differentiated patients with a TTR less than 65%. Conclusions: The SAMe-TT2R2 model differentiated Australian patients with reduced warfarin control, despite the exclusion of race. In Australia, the SAMe-TT2R2 score could assist clinicians in identifying Australian patients who may obtain reduced warfarin control and benefit from additional interventions such as a dedicated WCP.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofissue6
dc.relation.ispartofjournalJournal of Clinical Medicine
dc.relation.ispartofvolume8
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode32
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsMedicine, General & Internal
dc.subject.keywordsGeneral & Internal Medicine
dc.subject.keywordsoral anticoagulant
dc.titleThe SAMe-TT2R2 Score Predicts Warfarin Control in an Australian Population with Atrial Fibrillation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBernaitis, N; Clark, G; Kohja, S; Leong, S; Anoopkumar-Dukie, S, The SAMe-TT2R2 Score Predicts Warfarin Control in an Australian Population with Atrial Fibrillation, Journal of Clinical Medicine, 2019, 8 (6)
dcterms.dateAccepted2019-06-15
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-09-19T22:34:31Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2019 by the Authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorBernaitis, Nijole L.
gro.griffith.authorAnoopkumar-Dukie, Shailendra


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