dc.contributor.author | Nel, Karen | |
dc.contributor.author | Nam, Michael CY | |
dc.contributor.author | Anstey, Chris | |
dc.contributor.author | Boos, Christopher J | |
dc.contributor.author | Carlton, Edward | |
dc.contributor.author | Senior, Roxy | |
dc.contributor.author | Kaski, Juan Carlos | |
dc.contributor.author | Khattab, Ahmed | |
dc.contributor.author | Shamley, Delva | |
dc.contributor.author | Byrne, Christopher D | |
dc.contributor.author | Stanton, Tony | |
dc.contributor.author | Greaves, Kim | |
dc.date.accessioned | 2019-09-20T01:27:09Z | |
dc.date.available | 2019-09-20T01:27:09Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0167-5273 | |
dc.identifier.doi | 10.1016/j.ijcard.2017.06.023 | |
dc.identifier.uri | http://hdl.handle.net/10072/387558 | |
dc.description.abstract | Background: Although calcific aortic valve disease (CAVD) is associated with coronary atherosclerosis, it is not known whether early CAVD is associated with coronary microcirculatory dysfunction (CMD). We sought to investigate the relationship between myocardial blood flow reserve (MBFR) - a measure of CMD, and early CAVD in the absence of obstructive epicardial coronary artery disease. We also determined whether this relationship was independent of coronary artery disease (CAD) and hs-CRP, a marker of systemic inflammation. Methods: 183 patients with chest pain and unobstructed coronary arteries were studied. Aortic valve calcification score (AVCS), coronary total plaque length (TPL), and coronary calcium score were quantified from multislice CT. MBFR was assessed using vasodilator myocardial contrast echocardiography. Hs-CRP was measured from venous blood using a particle-enhanced immunoassay. Results: Mean (± SD) participant age was 59.8 (9.6) years. Mean AVCS was 68 (258) AU, TPL was 15.6 (22.2) mm, and median coronary calcification score was 43.5 AU. Mean MBFR was 2.20 (0.52). Mean hs-CRP was 2.52 (3.86) mg/l. Multivariable linear regression modelling incorporating demographics, coronary plaque characteristics, MBFR, and inflammatory markers, demonstrated that age (β = 0.05, 95% CI: 0.02, 0.08, P = 0.007), hs-CRP (β = 0.09, CI: 0.02, 0.16, P = 0.010) and diabetes (β = 1.03, CI: 0.08, 1.98, P = 0.033), were positively associated with AVCS. MBFR (β = − 0.87, CI: − 1.44, − 0.30, P = 0.003), BMI (β = − 0.11, CI: − 0.21, − 0.01, P = 0.033), and LDL (β = − 0.32, CI: − 0.61, − 0.03, P = 0.029) were negatively associated with AVCS. TPL and coronary calcium score were not independently associated with AVCS when included in the regression model. Conclusion: Coronary microvascular function as determined by measurement of myocardial blood flow reserve is independently associated with early CAVD. This effect is independent of the presence of coronary artery disease and also systemic inflammation. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 427 | |
dc.relation.ispartofpageto | 432 | |
dc.relation.ispartofjournal | International Journal of Cardiology | |
dc.relation.ispartofvolume | 248 | |
dc.subject.fieldofresearch | Cardiovascular medicine and haematology | |
dc.subject.fieldofresearch | Health services and systems | |
dc.subject.fieldofresearch | Public health | |
dc.subject.fieldofresearchcode | 3201 | |
dc.subject.fieldofresearchcode | 4203 | |
dc.subject.fieldofresearchcode | 4206 | |
dc.subject.keywords | Science & Technology | |
dc.subject.keywords | Life Sciences & Biomedicine | |
dc.subject.keywords | Cardiac & Cardiovascular Systems | |
dc.subject.keywords | Cardiovascular System & Cardiology | |
dc.subject.keywords | Aortic valve calcification score | |
dc.title | Myocardial blood flow reserve is impaired in patients with aortic valve calcification and unobstructed epicardial coronary arteries | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Nel, K; Nam, MCY; Anstey, C; Boos, CJ; Carlton, E; Senior, R; Kaski, JC; Khattab, A; Shamley, D; Byrne, CD; Stanton, T; Greaves, K, Myocardial blood flow reserve is impaired in patients with aortic valve calcification and unobstructed epicardial coronary arteries, International Journal of Cardiology, 2017, 248, pp. 427-432 | |
dcterms.dateAccepted | 2017-06-07 | |
dcterms.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.date.updated | 2019-09-20T01:22:37Z | |
dc.description.version | Accepted Manuscript (AM) | |
gro.rights.copyright | © 2017 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Anstey, Chris | |