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dc.contributor.authorGouda, Hebe N
dc.contributor.authorCharlson, Fiona
dc.contributor.authorSorsdahl, Katherine
dc.contributor.authorAhmadzada, Sanam
dc.contributor.authorFerrari, Alize J
dc.contributor.authorErskine, Holly
dc.contributor.authorLeung, Janni
dc.contributor.authorSantamauro, Damian
dc.contributor.authorLund, Crick
dc.contributor.authorAminde, Leopold Ndemnge
dc.contributor.authorMayosi, Bongani M
dc.contributor.authorKengne, Andre Pascal
dc.contributor.authorHarris, Meredith
dc.contributor.authorAchoki, Tom
dc.contributor.authorWiysonge, Charles S
dc.contributor.authorStein, Dan J
dc.contributor.authorWhiteford, Harvey
dc.date.accessioned2019-09-20T06:02:08Z
dc.date.available2019-09-20T06:02:08Z
dc.date.issued2019
dc.identifier.issn2214-109X
dc.identifier.doi10.1016/s2214-109x(19)30374-2
dc.identifier.urihttp://hdl.handle.net/10072/387588
dc.description.abstractBackground: Although the burden of disease in sub-Saharan Africa continues to be dominated by infectious diseases, countries in this region are undergoing a demographic transition leading to increasing prevalence of non-communicable diseases (NCDs). To inform health system responses to these changing patterns of disease, we aimed to assess changes in the burden of NCDs in sub-Saharan Africa from 1990 to 2017. Methods: We used data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to analyse the burden of NCDs in sub-Saharan Africa in terms of disability-adjusted life-years (DALYs)—with crude counts as well as all-age and age-standardised rates per 100 000 population—with 95% uncertainty intervals (UIs). We examined changes in burden between 1990 and 2017, and differences across age, sex, and regions. We also compared the observed NCD burden across countries with the expected values based on a country's Socio-demographic Index. Findings: All-age total DALYs due to NCDs increased by 67·0% between 1990 (90·6 million [95% UI 81·0–101·9]) and 2017 (151·3 million [133·4–171·8]), reflecting an increase in the proportion of total DALYs attributable to NCDs (from 18·6% [95% UI 17·1–20·4] to 29·8% [27·6–32·0] of the total burden). Although most of this increase can be explained by population growth and ageing, the age-standardised DALY rate (per 100 000 population) due to NCDs in 2017 (21 757·7 DALYs [95% UI 19 377·1–24 380·7]) was almost equivalent to that of communicable, maternal, neonatal, and nutritional diseases (26 491·6 DALYs [25 165·2–28 129·8]). Cardiovascular diseases were the second leading cause of NCD burden in 2017, resulting in 22·9 million (21·5–24·3) DALYs (15·1% of the total NCD burden), after the group of disorders categorised as other NCDs (28·8 million [25·1–33·0] DALYs, 19·1%). These categories were followed by neoplasms, mental disorders, and digestive diseases. Although crude DALY rates for all NCDs have decreased slightly across sub-Saharan Africa, age-standardised rates are on the rise in some countries (particularly those in southern sub-Saharan Africa) and for some NCDs (such as diabetes and some cancers, including breast and prostate cancer). Interpretation: NCDs in sub-Saharan Africa are posing an increasing challenge for health systems, which have to date largely focused on tackling infectious diseases and maternal, neonatal, and child deaths. To effectively address these changing needs, countries in sub-Saharan Africa require detailed epidemiological data on NCDs. Funding: Bill & Melinda Gates Foundation, National Health and Medical Research Centre (Australia).
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrome1375
dc.relation.ispartofpagetoe1387
dc.relation.ispartofissue10
dc.relation.ispartofjournalThe Lancet Global Health
dc.relation.ispartofvolume7
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchcode1115
dc.subject.fieldofresearchcode1117
dc.subject.fieldofresearchcode0605
dc.titleBurden of non-communicable diseases in sub-Saharan Africa, 1990–2017: results from the Global Burden of Disease Study 2017
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGouda, HN; Charlson, F; Sorsdahl, K; Ahmadzada, S; Ferrari, AJ; Erskine, H; Leung, J; Santamauro, D; Lund, C; Aminde, LN; Mayosi, BM; Kengne, AP; Harris, M; Achoki, T; Wiysonge, CS; Stein, DJ; Whiteford, H, Burden of non-communicable diseases in sub-Saharan Africa, 1990–2017: results from the Global Burden of Disease Study 2017, The Lancet Global Health, 2019, 7 (10), pp. e1375-e1387
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-09-20T02:42:11Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorAminde, Leopold N.


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