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dc.contributor.authorMinahan, Clare
dc.contributor.authorO'Neill, Hailey
dc.contributor.authorSikkema, Nelie
dc.contributor.authorJoyce, Sarah
dc.contributor.authorLarsen, Brianna
dc.contributor.authorSabapathy, Surendran
dc.date.accessioned2019-09-23T00:27:42Z
dc.date.available2019-09-23T00:27:42Z
dc.date.issued2018
dc.identifier.issn2051-817X
dc.identifier.doi10.14814/phy2.13629
dc.identifier.urihttp://hdl.handle.net/10072/387609
dc.description.abstractWe sought to determine whether oral contraception alters the gender-related differences observed in the exercise pressor reflex during isometric handgrip exercise. Fifteen men, fifteen normally menstruating women (WomenNM), and fifteen women taking monophasic oral contraceptives (WomenOC) completed two trials of a 3-min isometric handgrip exercise protocol performed at 30% of their maximal voluntary contraction: (1) where arterial occlusion was applied to the previously exercising arm during a 3-min recovery period (Occlusion trial); (2) where no arterial occlusion was applied during recovery (Control trial). Handgrip exercise elicited greater increases in mean arterial pressure (MAP) in MEN compared to both female groups (P < 0.05), and in WomenOC compared to WomenNM in both trials (P = 0.01, P = 0.03). After 3 min of recovery, sBP was 12% (P = 0.01) and 9% (P = 0.02) higher in the Occlusion trial when compared to the Control trial for MEN and WomenOC. Conversely, arterial occlusion in recovery from handgrip did not sustain elevated sBP in the Occlusion trial, and sBP returned to recovery levels not different to the Control trial, in WomenNM (P = 0.41). These data indicate that gender-related differences in the metaboreflex during isometric handgrip exercise exist between men and normally menstruating women, but are blunted when men are compared to women taking oral contraceptives. We conclude that the suppression of 17β-estradiol and/or progestogen in women via the administration of oral contraceptives attenuates sex-related differences in the metaboreflex during isometric handgrip exercise.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley Blackwell
dc.relation.ispartofpagefrome13629:1
dc.relation.ispartofpagetoe13629:8
dc.relation.ispartofissue5
dc.relation.ispartofjournalPhysiological Reports
dc.relation.ispartofvolume6
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3208
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywords17 beta-estradiol
dc.subject.keywordscontraception
dc.titleOral contraceptives augment the exercise pressor reflex during isometric handgrip exercise
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMinahan, C; O'Neill, H; Sikkema, N; Joyce, S; Larsen, B; Sabapathy, S, Oral contraceptives augment the exercise pressor reflex during isometric handgrip exercise, Physiological Reports, 2018, 6 (5), pp. e13629:1-e13629:8
dcterms.dateAccepted2018-01-24
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-09-23T00:22:30Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorSabapathy, Surendran
gro.griffith.authorMinahan, Clare L.
gro.griffith.authorO'Neill, Hailey


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