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dc.contributor.authorLeng, Jing
dc.contributor.authorHou, Jin-gang
dc.contributor.authorFu, Cheng-lin
dc.contributor.authorRen, Shen
dc.contributor.authorJiang, Shuang
dc.contributor.authorWang, Ying-ping
dc.contributor.authorChen, Chen
dc.contributor.authorWang, Zi
dc.contributor.authorLi, Wei
dc.date.accessioned2019-09-23T03:26:45Z
dc.date.available2019-09-23T03:26:45Z
dc.date.issued2019
dc.identifier.issn1756-4646
dc.identifier.doi10.1016/j.jff.2019.01.050
dc.identifier.urihttp://hdl.handle.net/10072/387639
dc.description.abstractThe aim of the present study was designed to investigate that Platycodon grandiflorum saponins (PGS) exerted protective effects against testicular injury induced by scrotal hyperthermia. PGS (15, 30 mg/kg) were administered intragastrically to mice for 14 days, then exposed to a single scrotal heat treatment at 43 °C for 18 min on the 7th day. Heat stress (HS) induced spermatogenic damage was associated with a significant loss of leydig cells and the changes of serum testosterone, oxidative stress and apoptosis markers, and activated MAPK signaling pathway. In contrast, PGS treatment normalized HS-induced histopathological changes and prevented the activation of MAPK signaling pathway, which was contributed to oxidative stress and apoptosis in the testis of treated mice. In conclusion, our findings clearly demonstrated that PGS exhibited a significant protective effect against HS-induced testicular dysfunction, largely dependent upon the inhibition of oxidative stress associated apoptosis via partly regulation of MAPK signaling pathway.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom479
dc.relation.ispartofpageto488
dc.relation.ispartofjournalJournal of Functional Foods
dc.relation.ispartofvolume54
dc.subject.fieldofresearchFood Sciences
dc.subject.fieldofresearchNutrition and Dietetics
dc.subject.fieldofresearchMedical Physiology
dc.subject.fieldofresearchcode0908
dc.subject.fieldofresearchcode1111
dc.subject.fieldofresearchcode1116
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsFood Science & Technology
dc.subject.keywordsPlatycodon grandiflorum Saponins
dc.titlePlatycodon grandiflorum Saponins attenuate scrotal heat-induced spermatogenic damage via inhibition of oxidative stress and apoptosis in mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationLeng, J; Hou, J-G; Fu, C-L; Ren, S; Jiang, S; Wang, Y-P; Chen, C; Wang, Z; Li, W, Platycodon grandiflorum Saponins attenuate scrotal heat-induced spermatogenic damage via inhibition of oxidative stress and apoptosis in mice, Journal of Functional Foods, 2019, 54, pp. 479-488
dc.date.updated2019-09-23T03:24:54Z
gro.hasfulltextNo Full Text
gro.griffith.authorChen, Chen


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