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  • The interaction between positive schizotypy and high sensitivity C-reactive protein on response inhibition in female individuals

    Author(s)
    Gong, J
    Wang, Y
    Liu, J
    Fu, X
    Cheung, EFC
    Chan, RCK
    Griffith University Author(s)
    Chan, Raymond
    Year published
    2019
    Metadata
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    Abstract
    This study aimed to measure the associations between high sensitivity C-reactive protein (hsCRP), childhood maltreatment (CM), schizotypy and response inhibition, and to explore the interactions between hsCRP, CM and schizotypy on response inhibition. Two hundred and fourteen participants completed the Stop-Signal Task (SST), the Schizotypy Personality Questionnaire (SPQ) and the Childhood Trauma Questionnaire-Short Form (CTQ), which measured response inhibition, schizotypy and history of CM respectively. The level of hsCRP was also measured. The high schizotypy group (n = 114) had higher scores on SPQ and CTQ, higher hsCRP ...
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    This study aimed to measure the associations between high sensitivity C-reactive protein (hsCRP), childhood maltreatment (CM), schizotypy and response inhibition, and to explore the interactions between hsCRP, CM and schizotypy on response inhibition. Two hundred and fourteen participants completed the Stop-Signal Task (SST), the Schizotypy Personality Questionnaire (SPQ) and the Childhood Trauma Questionnaire-Short Form (CTQ), which measured response inhibition, schizotypy and history of CM respectively. The level of hsCRP was also measured. The high schizotypy group (n = 114) had higher scores on SPQ and CTQ, higher hsCRP levels and longer SST reaction times (SSRTs) than the low schizotypy group (n = 100). In female participants, SSRT had a positive correlation with the SPQ positive factor and the disorganized SPQ factor and a positive correlation with physical neglect. HsCRP was positively correlated with the SPQ negative factor and positive SPQ factor. In male participants, SSRT was negatively correlated with emotional neglect and physical neglect. The majority of correlations between CTQ and SPQ variables were significant in both female and male participants. In female participants, hsCRP significantly predicted SSRT, and hsCRP significantly interacted with positive schizotypy in predicting SSRT.
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    Journal Title
    Psychiatry Research
    Volume
    274
    DOI
    https://doi.org/10.1016/j.psychres.2019.02.064
    Subject
    Biomedical and clinical sciences
    Psychology
    Childhood maltreatment
    High sensitive C-reactive protein
    Response inhibition
    Schizotypy
    Publication URI
    http://hdl.handle.net/10072/387647
    Collection
    • Journal articles

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