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dc.contributor.authorNg, MSY
dc.contributor.authorHay, K
dc.contributor.authorChoy, J
dc.contributor.authorMiddelburg, RA
dc.contributor.authorTung, JP
dc.contributor.authorFraser, JF
dc.date.accessioned2019-09-26T03:42:44Z
dc.date.available2019-09-26T03:42:44Z
dc.date.issued2019
dc.identifier.issn0042-9007
dc.identifier.doi10.1111/vox.12838
dc.identifier.urihttp://hdl.handle.net/10072/387775
dc.description.abstractBackground and Objectives: To date, the effects of FFP and PC storage duration on mortality have only been studied in a few studies in limited patient subpopulations. The aim of the current study was to determine whether FFP and PC storage duration is associated with increased in hospital mortality risk across cardiac surgery, acute medicine, ICU and orthopaedic surgery patients. Materials and Methods: Two‐stage individual patient data meta‐analyses were performed to determine the effects of FFP and PC storage duration on in hospital mortality. Preset random effects models were used to determine pooled unadjusted and adjusted (adjusted for age, gender and units of product transfused) effect estimates. Results: The FFP storage duration analysis included 3625 patients across four studies. No significant association was observed between duration of storage and in hospital mortality in unadjusted analysis, but after adjusting for patient age, gender and units of product a small increased risk of in hospital mortality was observed for each additional month of storage (OR: 1·05, 95% CI: 1·01–1·08). This effect was no longer statistically significant when donor ABO blood group was incorporated into the random effects model on post hoc analyses. A total of 547 patients across five studies were incorporated in the PC storage duration analysis. No association was observed between PC storage duration and odds of in hospital morality (adjusted OR: 0·94, 95% CI: 0·79–1·11). Conclusions: There is insufficient evidence to support shortening FFP or PC shelf life based on in hospital mortality.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.publisher.placeUnited Kingdom
dc.relation.ispartofjournalVox Sanguinis
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchMedical Physiology
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1116
dc.titleFresh frozen plasma and platelet concentrate storage duration not associated with in hospital mortality risk
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationNg, MSY; Hay, K; Choy, J; Middelburg, RA; Tung, JP; Fraser, JF, Fresh frozen plasma and platelet concentrate storage duration not associated with in hospital mortality risk, Vox Sanguinis, 2019
dcterms.dateAccepted2019-07-26
dc.date.updated2019-09-26T03:38:12Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2019 International Society of Blood Transfusion. This is the peer reviewed version of the following article: Fresh frozen plasma and platelet concentrate storage duration not associated with in hospital mortality risk, Vox Sanguinis, which has been published in final form at 10.1111/vox.12838. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.hasfulltextFull Text
gro.griffith.authorFraser, John F.


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