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dc.contributor.authorRickard, Claire M
dc.contributor.authorUllman, Amanda J
dc.date.accessioned2019-09-27T04:08:50Z
dc.date.available2019-09-27T04:08:50Z
dc.date.issued2018
dc.identifier.issn1473-3099
dc.identifier.doi10.1016/S1473-3099(18)30267-6
dc.identifier.urihttp://hdl.handle.net/10072/387854
dc.description.abstractOne in ten children with a central venous catheter (CVC) develops a central line-associated bloodstream infection (CLABSI),1 which is a life-threatening complication and harmful distraction from time-sensitive treatment. However, across CVC types (figure), device occlusion is also troublesome and might increase CLABSI risk, presumably through the complementary interactions of fibrin, thrombus, and biofilms.2 The question arises as to what antimicrobial, antithrombotic, or other solution can be periodically instilled (known as locked) within the CVC to prevent one, or preferably both, of these complications. Furthermore, which solutions could effectively treat such complications, should they arise, without needing to remove the CVC? Few high-quality randomised controlled trials have addressed these questions, and it is difficult to find two health-care institutions that share identical policies for lock solution type, concentration, frequency, or duration of dwell. This situation has probably resulted in preventable injuries in children who rely on CVCs to administer treatment.
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom815
dc.relation.ispartofpageto817
dc.relation.ispartofissue8
dc.relation.ispartofjournalThe Lancet Infectious Diseases
dc.relation.ispartofvolume18
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchMedical Microbiology
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1108
dc.subject.fieldofresearchcode1117
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsInfectious Diseases
dc.titleBloodstream infection and occlusion of central venous catheters in children
dc.typeJournal article
dc.type.descriptionC2 - Articles (Other)
dcterms.bibliographicCitationRickard, CM; Ullman, AJ, Bloodstream infection and occlusion of central venous catheters in children, The Lancet Infectious Diseases, 2018, 18 (8), pp. 815-817
dcterms.dateAccepted2018-04-11
dc.date.updated2019-09-27T04:06:41Z
gro.hasfulltextNo Full Text
gro.griffith.authorRickard, Claire
gro.griffith.authorUllman, Amanda J.


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