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dc.contributor.authorTeixeira, MKS
dc.contributor.authorLira-Junior, R
dc.contributor.authorLourenço, EJV
dc.contributor.authorTelles, DM
dc.contributor.authorBoström, EA
dc.contributor.authorFigueredo, CM
dc.contributor.authorBostanci, N
dc.date.accessioned2019-09-27T05:44:00Z
dc.date.available2019-09-27T05:44:00Z
dc.date.issued2019
dc.identifier.issn1432-6981
dc.identifier.doi10.1007/s00784-019-03047-z
dc.identifier.urihttp://hdl.handle.net/10072/387867
dc.description.abstractObjectives: The aim of this study is to investigate the expression of sTREM-1 and its ligand PGLYRP1, as well as the expression of MMP-8 and its inhibitor TIMP-1, in peri-implant diseases. As a secondary aim, we analyzed the influence of the concomitant existence of periodontitis in the expression of these biomarkers. Materials and methods: This study included 77 patients (29 males and 48 females; mean age 55.0 ± 11.5), 18 having gingivitis, 16 having periodontitis, 20 having mucositis, and 23 having peri-implantitis. Patients were clinically examined, and unstimulated whole saliva was collected. sTREM-1, PGLYRP1, MMP-8, TIMP-1, and MMP-8/TIMP1 ratio were determined by ELISA. Results: The periodontitis group presented higher probing depth (PD) mean, and higher clinical attachment loss, compared with the other groups. The peri-implantitis group presented higher PD mean in implants compared to the mucositis group. Patients with PD ≥ 6 mm showed significantly higher levels of PGLYRP1, MMP-8, and MMP-8/TIMP-1 ratio than patients with PD < 6 mm. When all four markers were assessed, there were no significant differences between mucositis and peri-implantitis groups. Concomitant periodontitis resulted in higher significant levels of MMP-8 in patients with peri-implant disease. Conclusion: We did not observe significant differences in the levels of the sTREM-1/PGLYRP1/MMP-8 axis between patients with periodontal and peri-implant diseases, suggesting that these markers are also involved in the inflammatory process around implants. Besides, the presence of periodontitis may affect the levels of MMP-8 in patients with peri-implant disease. Clinical relevance: The sTREM-1/PGLYRP1/MMP-8 axis could be useful as potent markers in periodontal and peri-implant diseases.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeGermany
dc.relation.ispartofjournalClinical Oral Investigations
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchcode1105
dc.titleThe modulation of the TREM-1/PGLYRP1/MMP-8 axis in peri-implant diseases
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationTeixeira, MKS; Lira-Junior, R; Lourenço, EJV; Telles, DM; Boström, EA; Figueredo, CM; Bostanci, N, The modulation of the TREM-1/PGLYRP1/MMP-8 axis in peri-implant diseases, Clinical Oral Investigations, 2019
dc.date.updated2019-09-27T03:35:54Z
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version
gro.hasfulltextNo Full Text
gro.griffith.authorda Silva Figueredo, Carlos Marcelo


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