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dc.contributor.authorD'Isidoro, Orlando
dc.contributor.authorPerrotti, Vittoria
dc.contributor.authorHui, Wang Lai
dc.contributor.authorPiattelli, Adrian
dc.contributor.authorIaculli, Flavia
dc.contributor.authorQuaranta, Alessandro
dc.date.accessioned2019-09-30T23:02:35Z
dc.date.available2019-09-30T23:02:35Z
dc.date.issued2019
dc.identifier.issn0894-8275
dc.identifier.urihttp://hdl.handle.net/10072/387880
dc.description.abstractPURPOSE: To review the literature on the effects of non-surgical periodontal treatment on surrogate markers of cardiovascular diseases (CVDs) and to clarify the impact of periodontal disease on systemic inflammation. METHODS: PRISMA guidelines for systematic reviews and meta-analyses have been adopted. An electronic search in PubMed up to December 2018 was performed using the following search terms and keywords alone or in combination: non surgical periodontal therapy, atherosclerotic vascular disease (AVD), operative surgical procedures, CVD, IL-6, CRP, cholesterol, LDL, oxidized low density lipoprotein, HDL, endothelial dysfunction, dependent dilatation, carotid intima media thickness, periodontitis, tunica intima. RESULTS: The electronic search resulted in the inclusion of 28 articles that were grouped and discussed based on the investigated surrogate markers. Meta-analysis was not carried out due to the heterogeneity of the results. The included studies demonstrated that periodontal treatments contribute to the resolution of oral inflammation and in turn might positively modulate the levels of systemic inflammatory markers. The initial phase of periodontal therapy has a positive impact on the short-term reduction of a series of systemic markers that are considered as surrogate markers of AVD. CLINICAL SIGNIFICANCE: The non-surgical therapy of periodontal disease would positively reduce the levels of systemic inflammation markers, decreasing the vascular risk and the possibility of developing CVD or the subclinical progression of the disease.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMosher & Linder, Inc.
dc.publisher.urihttp://www.amjdent.com/Archive/2019/August%202019%20Issue.html
dc.relation.ispartofpagefrom191
dc.relation.ispartofpageto200
dc.relation.ispartofissue4
dc.relation.ispartofjournalAmerican Journal of Dentistry
dc.relation.ispartofvolume32
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchcode3203
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsDentistry, Oral Surgery & Medicine
dc.subject.keywordsC-REACTIVE PROTEIN
dc.subject.keywordsINTIMA-MEDIA THICKNESS
dc.titleThe impact of non-surgical therapy of periodontal disease on surrogate markers for cardiovascular disease: A literature review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationD'Isidoro, O; Perrotti, V; Hui, WL; Piattelli, A; Iaculli, F; Quaranta, A, The impact of non-surgical therapy of periodontal disease on surrogate markers for cardiovascular disease: A literature review, American Journal of Dentistry, 2019, 32 (4), pp. 191-200
dc.date.updated2019-09-29T23:34:56Z
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
gro.hasfulltextNo Full Text
gro.griffith.authorQuaranta, Alex


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