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dc.contributor.authorSun, Qi
dc.contributor.authorTan, Say Hwa
dc.contributor.authorChen, Qiushui
dc.contributor.authorRan, Rui
dc.contributor.authorHui, Yue
dc.contributor.authorChen, Dong
dc.contributor.authorZhao, Chun-Xia
dc.date.accessioned2019-09-30T03:21:26Z
dc.date.available2019-09-30T03:21:26Z
dc.date.issued2018
dc.identifier.issn2373-9878
dc.identifier.doi10.1021/acsbiomaterials.8b00904
dc.identifier.urihttp://hdl.handle.net/10072/387909
dc.description.abstractThree-dimensional (3D) tumor spheroids offer unprecedented capability for drug screening because of their unique features such as spatial 3D structure, relevant physiological responses, more complex intercellular network, and stroma-cancer cell interactions. Microfluidic technology provides a facile strategy to make uniform tumor spheroids with potential of high-throughput production. In this article, we develop a microfluidic approach to produce core-shell alginate particles, which allows the separate confinement of different cells in the core and shell structure. To reconstitute the complex tumor structure, we encapsulated tumor cells in the core and stromal fibroblast cells in the shell. These coculture tumor spheroids were applied for drug evaluation showing similar drug resistance as those prepared using conventional methods in well plates. These results demonstrated that our microfluidic approach are facile and versatile for making various tumor spheroids with uniform size but different components to better mimic tumor microenvironment. Moreover, the production rate of around 200 spheroids/min indicates the great potential of this approach for high-throughput drug screening.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAMER CHEMICAL SOC
dc.relation.ispartofpagefrom4425
dc.relation.ispartofpageto4433
dc.relation.ispartofissue12
dc.relation.ispartofjournalACS Biomaterials Science & Engineering
dc.relation.ispartofvolume4
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchcode0903
dc.subject.keywordsScience & Technology
dc.subject.keywordsTechnology
dc.subject.keywordsMaterials Science, Biomaterials
dc.subject.keywordsmicrofluidic
dc.titleMicrofluidic Formation of Coculture Tumor Spheroids with Stromal Cells As a Novel 3D Tumor Model for Drug Testing
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSun, Q; Tan, SH; Chen, Q; Ran, R; Hui, Y; Chen, D; Zhao, C-X, Microfluidic Formation of Coculture Tumor Spheroids with Stromal Cells As a Novel 3D Tumor Model for Drug Testing, ACS Biomaterials Science & Engineering, 2018, 4 (12), pp. 4425-4433
dc.date.updated2019-09-30T03:19:18Z
gro.hasfulltextNo Full Text
gro.griffith.authorTan, Say Hwa H.


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