dc.contributor.author | Newbould, BB | |
dc.contributor.author | Pearson, CM | |
dc.contributor.author | Whitehouse, MW | |
dc.date.accessioned | 2019-09-30T04:30:03Z | |
dc.date.available | 2019-09-30T04:30:03Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0925-4692 | |
dc.identifier.doi | 10.1007/s10787-019-00565-w | |
dc.identifier.uri | http://hdl.handle.net/10072/387945 | |
dc.description.abstract | 1. A strategy is described for evaluating drugs against different phases in the development of an auto allergic disease, experimental allergic encephalomyelitis. It is based on a cell transfer technique whereby the disease is passively transferred with lymphoid cells from actively immunized donor rats to normal syngeneic rats = passive recipients. Drugs may be applied in vivo to either the cell donors or the cell recipients or to cells in vitro whilst in transit; their efficiency being determined by the severity of the passive disease (weight loss, paralysis) in the recipients.
2. Examples are given illustrating the application of these techniques to:
(a) evaluating the lymphocyte-deactivating activity of various nitrogen mustards in vitro;
(b) recognizing drugs, e.g. gold derivatives, clofazimine, etc. that are not conventional immunosuppressant (or cytostatic) agents which, when given to the recipient animals, may prevent the expression of the adopted disease;
(c) comparing some known immunosuppressants for potency, duration of action, etc.;
(d) demonstrating the versatility of cycloleucine, ICI-47,776, etc.
3. Some merits of the strategy are discussed vis a vis using the local graft-versus-host reaction in rats to search for new drugs. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.relation.ispartofjournal | Inflammopharmacology | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences | |
dc.subject.fieldofresearchcode | 3214 | |
dc.subject.keywords | Drug evaluation against PL | |
dc.subject.keywords | Experimental allergic encephalomyelitis (EAE) | |
dc.subject.keywords | Multiple sclerosis (MS) | |
dc.subject.keywords | Pathophoric lymphocytes (PL) | |
dc.title | Passive transfer of allergic encephalomyelitis in rats: a tool for drug mechanism studies and detecting late-acting immunosuppressants | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Newbould, BB; Pearson, CM; Whitehouse, MW, Passive transfer of allergic encephalomyelitis in rats: a tool for drug mechanism studies and detecting late-acting immunosuppressants, Inflammopharmacology, 2019 | |
dcterms.dateAccepted | 2019-01-16 | |
dc.date.updated | 2019-09-30T04:27:07Z | |
gro.description.notepublic | This publication has been entered into Griffith Research Online as an Advanced Online Version. | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Whitehouse, Michael | |