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dc.contributor.authorNewbould, BB
dc.contributor.authorPearson, CM
dc.contributor.authorWhitehouse, MW
dc.date.accessioned2019-09-30T04:30:03Z
dc.date.available2019-09-30T04:30:03Z
dc.date.issued2019
dc.identifier.issn0925-4692
dc.identifier.doi10.1007/s10787-019-00565-w
dc.identifier.urihttp://hdl.handle.net/10072/387945
dc.description.abstract1. A strategy is described for evaluating drugs against different phases in the development of an auto allergic disease, experimental allergic encephalomyelitis. It is based on a cell transfer technique whereby the disease is passively transferred with lymphoid cells from actively immunized donor rats to normal syngeneic rats = passive recipients. Drugs may be applied in vivo to either the cell donors or the cell recipients or to cells in vitro whilst in transit; their efficiency being determined by the severity of the passive disease (weight loss, paralysis) in the recipients. 2. Examples are given illustrating the application of these techniques to: (a) evaluating the lymphocyte-deactivating activity of various nitrogen mustards in vitro; (b) recognizing drugs, e.g. gold derivatives, clofazimine, etc. that are not conventional immunosuppressant (or cytostatic) agents which, when given to the recipient animals, may prevent the expression of the adopted disease; (c) comparing some known immunosuppressants for potency, duration of action, etc.; (d) demonstrating the versatility of cycloleucine, ICI-47,776, etc. 3. Some merits of the strategy are discussed vis a vis using the local graft-versus-host reaction in rats to search for new drugs.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofjournalInflammopharmacology
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3214
dc.subject.keywordsDrug evaluation against PL
dc.subject.keywordsExperimental allergic encephalomyelitis (EAE)
dc.subject.keywordsMultiple sclerosis (MS)
dc.subject.keywordsPathophoric lymphocytes (PL)
dc.titlePassive transfer of allergic encephalomyelitis in rats: a tool for drug mechanism studies and detecting late-acting immunosuppressants
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationNewbould, BB; Pearson, CM; Whitehouse, MW, Passive transfer of allergic encephalomyelitis in rats: a tool for drug mechanism studies and detecting late-acting immunosuppressants, Inflammopharmacology, 2019
dcterms.dateAccepted2019-01-16
dc.date.updated2019-09-30T04:27:07Z
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorWhitehouse, Michael


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