The global macroeconomic burden of epilepsy and the role for neurosurgery: A modelling study based upon the 2016 Global Burden of Disease data
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Author(s)
O'Donohoe, Tom J
Choudhury, Adnan
Callander, Emily
Griffith University Author(s)
Year published
2019
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Background: Although the significant morbidity and mortality burden associated with epilepsy is well understood, associated economic consequences have not been estimated on a global scale. We sought to; (1) estimate the value of lost economic welfare attributable to epilepsy among countries included in the 2016 Global Burden of Disease study, (2) evaluate differences in disease burden between countries of varied income classification and location, and (3) understand the proportion of this burden that requires neurosurgical consultation and intervention.
Methods: Publicly available morbidity and mortality data were incorporated ...
View more >Background: Although the significant morbidity and mortality burden associated with epilepsy is well understood, associated economic consequences have not been estimated on a global scale. We sought to; (1) estimate the value of lost economic welfare attributable to epilepsy among countries included in the 2016 Global Burden of Disease study, (2) evaluate differences in disease burden between countries of varied income classification and location, and (3) understand the proportion of this burden that requires neurosurgical consultation and intervention. Methods: Publicly available morbidity and mortality data were incorporated into a ‘full‐income’ model to generate estimates of the cumulative value of lost welfare (VLW) related to epilepsy. Results from a survey of neurosurgeons were then used to estimate the VLW attributable to the proportion of disease requiring neurosurgical consultation and intervention. Results: A total of 195 countries and territories were included in this analysis. We estimate that the cumulative VLW related to epilepsy was $647.37 billion (2016 USD, PPP). Economic welfare losses were equivalent to a mean of 1.45% (± 1.00) of gross domestic product. The value of economic losses attributable to the proportion of the burden necessitating neurosurgical consultation and intervention was $258.95 billion (2016 USD, PPP) and $155.37 (2016 USD, PPP) respectively. Conclusions: Our results indicate that the economic consequences of epilepsy related morbidity and mortality are substantial. When considered with evidence supporting the cost‐effectiveness of various interventions for improved epilepsy diagnosis and management, our findings suggest that the implementation of simple and affordable measures may avert significant economic loss.
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View more >Background: Although the significant morbidity and mortality burden associated with epilepsy is well understood, associated economic consequences have not been estimated on a global scale. We sought to; (1) estimate the value of lost economic welfare attributable to epilepsy among countries included in the 2016 Global Burden of Disease study, (2) evaluate differences in disease burden between countries of varied income classification and location, and (3) understand the proportion of this burden that requires neurosurgical consultation and intervention. Methods: Publicly available morbidity and mortality data were incorporated into a ‘full‐income’ model to generate estimates of the cumulative value of lost welfare (VLW) related to epilepsy. Results from a survey of neurosurgeons were then used to estimate the VLW attributable to the proportion of disease requiring neurosurgical consultation and intervention. Results: A total of 195 countries and territories were included in this analysis. We estimate that the cumulative VLW related to epilepsy was $647.37 billion (2016 USD, PPP). Economic welfare losses were equivalent to a mean of 1.45% (± 1.00) of gross domestic product. The value of economic losses attributable to the proportion of the burden necessitating neurosurgical consultation and intervention was $258.95 billion (2016 USD, PPP) and $155.37 (2016 USD, PPP) respectively. Conclusions: Our results indicate that the economic consequences of epilepsy related morbidity and mortality are substantial. When considered with evidence supporting the cost‐effectiveness of various interventions for improved epilepsy diagnosis and management, our findings suggest that the implementation of simple and affordable measures may avert significant economic loss.
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Journal Title
European Journal of Neurology
Copyright Statement
© 2019 EFNS. This is the peer reviewed version of the following article: The global macroeconomic burden of epilepsy and the role for neurosurgery: A modelling study based upon the 2016 Global Burden of Disease data, European Journal of Neurology, which has been published in final form at 10.1111/ene.14085. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
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This publication has been entered into Griffith Research Online as an Advanced Online Version.
Subject
Clinical sciences
Neurosciences
Applied economics
Cost
Economics
Neurological Conditions
Neurosurgery
Value of Lost Welfare