dc.contributor.author O'Donohoe, Tom J dc.contributor.author Choudhury, Adnan dc.contributor.author Callander, Emily dc.date.accessioned 2019-10-03T03:35:47Z dc.date.available 2019-10-03T03:35:47Z dc.date.issued 2019 dc.identifier.issn 1351-5101 dc.identifier.doi 10.1111/ene.14085 dc.identifier.uri http://hdl.handle.net/10072/388027 dc.description.abstract Background: Although the significant morbidity and mortality burden associated with epilepsy is well understood, associated economic consequences have not been estimated on a global scale. We sought to; (1) estimate the value of lost economic welfare attributable to epilepsy among countries included in the 2016 Global Burden of Disease study, (2) evaluate differences in disease burden between countries of varied income classification and location, and (3) understand the proportion of this burden that requires neurosurgical consultation and intervention. Methods: Publicly available morbidity and mortality data were incorporated into a ‘full‐income’ model to generate estimates of the cumulative value of lost welfare (VLW) related to epilepsy. Results from a survey of neurosurgeons were then used to estimate the VLW attributable to the proportion of disease requiring neurosurgical consultation and intervention. Results: A total of 195 countries and territories were included in this analysis. We estimate that the cumulative VLW related to epilepsy was $647.37 billion (2016 USD, PPP). Economic welfare losses were equivalent to a mean of 1.45% (± 1.00) of gross domestic product. The value of economic losses attributable to the proportion of the burden necessitating neurosurgical consultation and intervention was$258.95 billion (2016 USD, PPP) and \$155.37 (2016 USD, PPP) respectively. Conclusions: Our results indicate that the economic consequences of epilepsy related morbidity and mortality are substantial. When considered with evidence supporting the cost‐effectiveness of various interventions for improved epilepsy diagnosis and management, our findings suggest that the implementation of simple and affordable measures may avert significant economic loss. dc.description.peerreviewed Yes dc.language English dc.language.iso eng dc.publisher Wiley-Blackwell dc.publisher.place United Kingdom dc.relation.ispartofjournal European Journal of Neurology dc.subject.fieldofresearch Clinical sciences dc.subject.fieldofresearch Neurosciences dc.subject.fieldofresearch Applied economics dc.subject.fieldofresearchcode 3202 dc.subject.fieldofresearchcode 3209 dc.subject.fieldofresearchcode 3801 dc.subject.keywords Cost dc.subject.keywords Economics dc.subject.keywords Neurological Conditions dc.subject.keywords Neurosurgery dc.subject.keywords Value of Lost Welfare dc.title The global macroeconomic burden of epilepsy and the role for neurosurgery: A modelling study based upon the 2016 Global Burden of Disease data dc.type Journal article dc.type.description C1 - Articles dcterms.bibliographicCitation O'Donohoe, TJ; Choudhury, A; Callander, E, The global macroeconomic burden of epilepsy and the role for neurosurgery: A modelling study based upon the 2016 Global Burden of Disease data., European Journal of Neurology, 2019 dc.date.updated 2019-10-02T23:45:50Z dc.description.version Accepted Manuscript (AM) gro.description.notepublic This publication has been entered into Griffith Research Online as an Advanced Online Version. gro.rights.copyright © 2019 EFNS. This is the peer reviewed version of the following article: The global macroeconomic burden of epilepsy and the role for neurosurgery: A modelling study based upon the 2016 Global Burden of Disease data, European Journal of Neurology, which has been published in final form at 10.1111/ene.14085. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html) gro.hasfulltext Full Text gro.griffith.author Callander, Emily J.
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