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dc.contributor.authorBuffart, Laurien M
dc.contributor.authorKalter, Joeri
dc.contributor.authorSweegers, Maike G
dc.contributor.authorCourneya, Kerry S
dc.contributor.authorNewton, Robert U
dc.contributor.authorAaronson, Neil K
dc.contributor.authorJacobsen, Paul B
dc.contributor.authorMay, Anne M
dc.contributor.authorGalvao, Daniel A
dc.contributor.authorChinapaw, Mai J
dc.contributor.authorSteindorf, Karen
dc.contributor.authorIrwin, Melinda L
dc.contributor.authorStuiver, Martijn M
dc.contributor.authorHayes, Sandi
dc.contributor.authorGriffith, Kathleen A
dc.contributor.authorLucia, Alejandro
dc.contributor.authorMesters, Ilse
dc.contributor.authorvan Weert, Ellen
dc.contributor.authorKnoop, Hans
dc.contributor.authorGoedendorp, Martine M
dc.contributor.authorMutrie, Nanette
dc.contributor.authorDaley, Amanda J
dc.contributor.authorMcConnachie, Alex
dc.contributor.authorBohus, Martin
dc.contributor.authorThorsen, Lene
dc.contributor.authorSchulz, Karl-Heinz
dc.contributor.authorShort, Camille E
dc.contributor.authorJames, Erica L
dc.contributor.authorPlotnikoff, Ron C
dc.contributor.authorArbane, Gill
dc.contributor.authorSchmidt, Martina E
dc.contributor.authorPotthoff, Karin
dc.contributor.authorvan Beurden, Marc
dc.contributor.authorOldenburg, Hester S
dc.contributor.authorSonke, Gabe S
dc.contributor.authorvan Harten, Wim H
dc.contributor.authorGarrod, Rachel
dc.contributor.authorSchmitz, Kathryn H
dc.contributor.authorWinters-Stone, Kerri M
dc.contributor.authorVelthuis, Miranda J
dc.contributor.authorTaaffe, Dennis R
dc.contributor.authorvan Mechelen, Willem
dc.contributor.authorKersten, Marie Jose
dc.contributor.authorNollet, Frans
dc.contributor.authorWenzel, Jennifer
dc.contributor.authorWiskemann, Joachim
dc.contributor.authorVerdonck-de Leeuw, Irma M
dc.contributor.authorBrug, Johannes
dc.date.accessioned2019-10-03T22:26:52Z
dc.date.available2019-10-03T22:26:52Z
dc.date.issued2017
dc.identifier.issn0305-7372
dc.identifier.doi10.1016/j.ctrv.2016.11.010
dc.identifier.urihttp://hdl.handle.net/10072/388038
dc.description.abstractThis individual patient data meta-analysis aimed to evaluate the effects of exercise on quality of life (QoL) and physical function (PF) in patients with cancer, and to identify moderator effects of demographic (age, sex, marital status, education), clinical (body mass index, cancer type, presence of metastasis), intervention-related (intervention timing, delivery mode and duration, and type of control group), and exercise-related (exercise frequency, intensity, type, time) characteristics. Relevant published and unpublished studies were identified in September 2012 via PubMed, EMBASE, PsycINFO, and CINAHL, reference checking and personal communications. Principle investigators of all 69 eligible trials were requested to share IPD from their study. IPD from 34 randomised controlled trials (n = 4519 patients) that evaluated the effects of exercise compared to a usual care, wait-list or attention control group on QoL and PF in adult patients with cancer were retrieved and pooled. Linear mixed-effect models were used to evaluate the effects of the exercise on post-intervention outcome values (z-score) adjusting for baseline values. Moderator effects were studies by testing interactions. Exercise significantly improved QoL (β = 0.15, 95%CI = 0.10;0.20) and PF (β = 0.18, 95%CI = 0.13;0.23). The effects were not moderated by demographic, clinical or exercise characteristics. Effects on QoL (βdifference_in_effect = 0.13, 95%CI = 0.03;0.22) and PF (βdifference_in_effect = 0.10, 95%CI = 0.01;0.20) were significantly larger for supervised than unsupervised interventions. In conclusion, exercise, and particularly supervised exercise, effectively improves QoL and PF in patients with cancer with different demographic and clinical characteristics during and following treatment. Although effect sizes are small, there is consistent empirical evidence to support implementation of exercise as part of cancer care.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom91
dc.relation.ispartofpageto104
dc.relation.ispartofjournalCancer Treatment Reviews
dc.relation.ispartofvolume52
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematology
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode1102
dc.subject.fieldofresearchcode1112
dc.subject.keywordsExercise
dc.subject.keywordsIndividual patient data meta-analysis
dc.subject.keywordsNeoplasm
dc.subject.keywordsPhysical function
dc.subject.keywordsQuality of life
dc.titleEffects and moderators of exercise on quality of life and physical function in patients with cancer: An individual patient data meta-analysis of 34 RCTs.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBuffart, et al., Effects and moderators of exercise on quality of life and physical function in patients with cancer: An individual patient data meta-analysis of 34 RCTs., Cancer Treatment Reviews, 2017, 52, pp. 91-104
dcterms.dateAccepted2016-11-25
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-10-03T06:06:06Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2017. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorHayes, Sandi C.


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