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dc.contributor.authorSingh, Ben
dc.contributor.authorSpence, Rosalind R
dc.contributor.authorSteele, Megan L
dc.contributor.authorSandler, Carolina X
dc.contributor.authorPeake, Jonathan M
dc.contributor.authorHayes, Sandra C
dc.date.accessioned2019-10-04T02:55:29Z
dc.date.available2019-10-04T02:55:29Z
dc.date.issued2018
dc.identifier.issn0003-9993
dc.identifier.doi10.1016/j.apmr.2018.03.026
dc.identifier.urihttp://hdl.handle.net/10072/388056
dc.description.abstractObjective: To systematically evaluate the safety, feasibility, and effect of exercise among women with stage II+ breast cancer. Data Sources: CINAHL, Cochrane, Ebscohost, MEDLINE, Pubmed, ProQuest Health and Medical Complete, ProQuest Nursing and Allied Health Source, Science Direct and SPORTDiscus were searched for articles published before March 1, 2017. Study Selection: Randomized, controlled, exercise trials involving at least 50% of women diagnosed with stage II+ breast cancer were included. Data Extraction: Risk of bias was assessed and adverse event severity was classified using the Common Terminology Criteria. Feasibility was evaluated by computing median (range) recruitment, withdrawal, and adherence rates. Meta-analyses were performed to evaluate exercise safety and effects on health outcomes only. The influence of intervention characteristics (mode, supervision, duration and timing) on exercise outcomes were also explored. Data Synthesis: There were no differences in adverse events between exercise and usual care (risk difference: <0.01 ([95% CI: -0.01, 0.01], P=0.38). Median recruitment rate was 56% (1%-96%), withdrawal rate was 10% (0%-41%) and adherence rate was 82% (44%-99%). Safety and feasibility outcomes were similar, irrespective of exercise mode, supervision, duration, or timing. Effects of exercise for quality of life, fitness, fatigue, strength, anxiety, depression, body mass index and waist circumference compared with usual care were significant (standardized mean difference range: 0.17-0.77, P<0.05). Conclusion: The findings support the safety, feasibility, and effects of exercise for those with stage II+ breast cancer, suggesting that national and international exercise guidelines appear generalizable to women with local, regional, and distant breast cancer.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom2621
dc.relation.ispartofpageto2636
dc.relation.ispartofissue12
dc.relation.ispartofjournalArchives of Physical Medicine and Rehabilitation
dc.relation.ispartofvolume99
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchOncology and carcinogenesis not elsewhere classified
dc.subject.fieldofresearchAllied health and rehabilitation science not elsewhere classified
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchAllied health and rehabilitation science
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.subject.fieldofresearchcode321199
dc.subject.fieldofresearchcode420199
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4201
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsRehabilitation
dc.subject.keywordsSport Sciences
dc.subject.keywordsBreast neoplasms
dc.titleA Systematic Review and Meta-Analysis of the Safety, Feasibility, and Effect of Exercise in Women With Stage II+ Breast Cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSingh, B; Spence, RR; Steele, ML; Sandler, CX; Peake, JM; Hayes, SC, A Systematic Review and Meta-Analysis of the Safety, Feasibility, and Effect of Exercise in Women With Stage II plus Breast Cancer, Archives of Physical Medicine and Rehabilitation, 2018, 99 (12), pp. 2621-2636
dcterms.dateAccepted2018-03-23
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2019-10-04T02:52:10Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2018 The American Congress of Rehabilitation Medicine. Published by Elsevier Ltd. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorSpence, Rosa


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