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dc.contributor.authorSweegers, Maike G
dc.contributor.authorAltenburg, Teatske M
dc.contributor.authorBrug, Johannes
dc.contributor.authorMay, Anne M
dc.contributor.authorvan Vulpen, Jonna K
dc.contributor.authorAaronson, Neil K
dc.contributor.authorArbane, Gill
dc.contributor.authorBohus, Martin
dc.contributor.authorCourneya, Kerry S
dc.contributor.authorDaley, Amanda J
dc.contributor.authorGalvao, Daniel A
dc.contributor.authorGarrod, Rachel
dc.contributor.authorGriffith, Kathleen A
dc.contributor.authorHayes, Sandra C
dc.contributor.authoret al.
dc.date.accessioned2019-10-08T23:37:47Z
dc.date.available2019-10-08T23:37:47Z
dc.date.issued2019
dc.identifier.issn0306-3674
dc.identifier.doi10.1136/bjsports-2018-099191
dc.identifier.urihttp://hdl.handle.net/10072/388137
dc.description.abstractNo commercial re-use. See rights and permissions. Published by BMJ. Objective To optimally target exercise interventions for patients with cancer, it is important to identify which patients benefit from which interventions. Design We conducted an individual patient data meta-analysis to investigate demographic, clinical, intervention-related and exercise-related moderators of exercise intervention effects on physical fitness in patients with cancer. Data sources We identified relevant studies via systematic searches in electronic databases (PubMed, Embase, PsycINFO and CINAHL). Eligibility criteria We analysed data from 28 randomised controlled trials investigating the effects of exercise on upper body muscle strength (UBMS) and lower body muscle strength (LBMS), lower body muscle function (LBMF) and aerobic fitness in adult patients with cancer. Results Exercise significantly improved UBMS (β=0.20, 95% Confidence Interval (CI) 0.14 to 0.26), LBMS (β=0.29, 95% CI 0.23 to 0.35), LBMF (β=0.16, 95% CI 0.08 to 0.24) and aerobic fitness (β=0.28, 95% CI 0.23 to 0.34), with larger effects for supervised interventions. Exercise effects on UBMS were larger during treatment, when supervised interventions included ≥3 sessions per week, when resistance exercises were included and when session duration was >60 min. Exercise effects on LBMS were larger for patients who were living alone, for supervised interventions including resistance exercise and when session duration was >60 min. Exercise effects on aerobic fitness were larger for younger patients and when supervised interventions included aerobic exercise. Conclusion Exercise interventions during and following cancer treatment had small effects on UBMS, LBMS, LBMF and aerobic fitness. Demographic, intervention-related and exercise-related characteristics including age, marital status, intervention timing, delivery mode and frequency and type and time of exercise sessions moderated the exercise effect on UBMS, LBMS and aerobic fitness.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBMJ Publishing Group Ltd
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom812: 1
dc.relation.ispartofpageto812: 13
dc.relation.ispartofissue13
dc.relation.ispartofjournalBritish Journal of Sports Medicine
dc.relation.ispartofvolume53
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchEducation
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode09
dc.subject.fieldofresearchcode13
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsSport Sciences
dc.subject.keywordsQUALITY-OF-LIFE
dc.subject.keywordsRANDOMIZED CONTROLLED-TRIAL
dc.titleEffects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer: a meta-analysis of individual patient data
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSweegers, MG; Altenburg, TM; Brug, J; May, AM; van Vulpen, JK; Aaronson, NK; Arbane, G; Bohus, M; Courneya, KS; Daley, AJ; Galvao, DA; Garrod, R; Griffith, KA; Van Harten, WH; Hayes, SC; Herrero-Roman, F; Kersten, MJ; Lucia, A; McConnachie, A; van Mechelen, W; Mutrie, N; Newton, RU; Nollet, F; Potthoff, K; Schmidt, ME; Schmitz, KH; Schulz, KH; Sonke, G; Steindorf, K; Stuiver, MM; Taaffe, DR; Thorsen, L; Twisk, JW; Velthuis, MJ; Wenzel, J; Winters-Stone, KM; Wiskemann, J; Paw, MJCA; Buffart, LM, Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer: a meta-analysis of individual patient data, British Journal of Sports Medicine, 2019, 53 (13), pp. 812: 1-812: 13
dcterms.dateAccepted2018-08-06
dc.date.updated2019-10-08T05:04:35Z
gro.hasfulltextNo Full Text
gro.griffith.authorHayes, Sandi C.


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