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  • Epicocconone-Hemicyanine Hybrids: Near Infrared Fluorophores for Protein Staining and Cell Imaging

    Author(s)
    Karuso, Peter
    Loa Kum Cheung, Wendy
    Peixoto, Philippe A
    Boulangé, Agathe
    Franck, Xavier
    Griffith University Author(s)
    Loa-Kum-Cheung, Wendy
    Year published
    2017
    Metadata
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    Abstract
    The development of new near infrared (NIR) dyes is crucial for diverse applications and especially bioimaging, as they absorb and emit light in the “therapeutic window“ (650–950 nm). We report here a new family of NIR fluorophores that has been obtained by hybridising hemicyanines with epicocconone. Emission wavelengths of these hybrid dyes is in the range 715–795 nm and is combined with large Stokes’ shifts (75–95 nm). The absorption and emission wavelength can be modulated according to the hemicyanine moiety and adding sulfonic acid moieties enhances water solubility. We demonstrate their application in the sensitive ...
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    The development of new near infrared (NIR) dyes is crucial for diverse applications and especially bioimaging, as they absorb and emit light in the “therapeutic window“ (650–950 nm). We report here a new family of NIR fluorophores that has been obtained by hybridising hemicyanines with epicocconone. Emission wavelengths of these hybrid dyes is in the range 715–795 nm and is combined with large Stokes’ shifts (75–95 nm). The absorption and emission wavelength can be modulated according to the hemicyanine moiety and adding sulfonic acid moieties enhances water solubility. We demonstrate their application in the sensitive detection of proteins in gel electrophoresis and the staining of specific cellular organelles in confocal microscopy. These results are particularly encouraging and bring forward a new fluorescent skeleton for chemical biology.
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    Journal Title
    Chemistry - A European Journal
    Volume
    23
    Issue
    8
    DOI
    https://doi.org/10.1002/chem.201604698
    Subject
    Chemical sciences
    Publication URI
    http://hdl.handle.net/10072/388195
    Collection
    • Journal articles

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