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dc.contributor.authorKaruso, Peter
dc.contributor.authorLoa Kum Cheung, Wendy
dc.contributor.authorPeixoto, Philippe A
dc.contributor.authorBoulangé, Agathe
dc.contributor.authorFranck, Xavier
dc.date.accessioned2019-10-09T06:09:30Z
dc.date.available2019-10-09T06:09:30Z
dc.date.issued2017
dc.identifier.issn0947-6539en_US
dc.identifier.doi10.1002/chem.201604698en_US
dc.identifier.urihttp://hdl.handle.net/10072/388195
dc.description.abstractThe development of new near infrared (NIR) dyes is crucial for diverse applications and especially bioimaging, as they absorb and emit light in the “therapeutic window“ (650–950 nm). We report here a new family of NIR fluorophores that has been obtained by hybridising hemicyanines with epicocconone. Emission wavelengths of these hybrid dyes is in the range 715–795 nm and is combined with large Stokes’ shifts (75–95 nm). The absorption and emission wavelength can be modulated according to the hemicyanine moiety and adding sulfonic acid moieties enhances water solubility. We demonstrate their application in the sensitive detection of proteins in gel electrophoresis and the staining of specific cellular organelles in confocal microscopy. These results are particularly encouraging and bring forward a new fluorescent skeleton for chemical biology.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherWileyen_US
dc.publisher.placeGermany
dc.relation.ispartofpagefrom1820en_US
dc.relation.ispartofpageto1829en_US
dc.relation.ispartofissue8en_US
dc.relation.ispartofjournalChemistry - A European Journalen_US
dc.relation.ispartofvolume23en_US
dc.subject.fieldofresearchChemical Sciencesen_US
dc.subject.fieldofresearchcode03en_US
dc.titleEpicocconone-Hemicyanine Hybrids: Near Infrared Fluorophores for Protein Staining and Cell Imagingen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationKaruso, P; Loa Kum Cheung, W; Peixoto, PA; Boulangé, A; Franck, X, Epicocconone-Hemicyanine Hybrids: Near Infrared Fluorophores for Protein Staining and Cell Imaging, Chemistry - A European Journal, 2017, 23 (8), pp. 1820-1829en_US
dc.date.updated2019-10-09T04:33:44Z
gro.hasfulltextNo Full Text
gro.griffith.authorLoa-Kum-Cheung, Wendy


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