Show simple item record

dc.contributor.authorHofstee, Pierre
dc.contributor.authorBartho, Lucy A
dc.contributor.authorMcKeating, Daniel R
dc.contributor.authorRadenkovic, Filip
dc.contributor.authorMcEnroe, Georgia
dc.contributor.authorFisher, Joshua J
dc.contributor.authorHolland, Olivia J
dc.contributor.authorVanderlelie, Jessica J
dc.contributor.authorPerkins, Anthony V
dc.contributor.authorCuffe, James SM
dc.date.accessioned2019-10-09T22:54:34Z
dc.date.available2019-10-09T22:54:34Z
dc.date.issued2019
dc.identifier.issn0022-3751
dc.identifier.doi10.1113/JP278473
dc.identifier.urihttp://hdl.handle.net/10072/388200
dc.description.abstractSelenium is a trace element fundamental to diverse homeostatic processes, including antioxidant regulation and thyroid hormone metabolism. Selenium deficiency in pregnancy is common and increases the risk of pregnancy complications including fetal growth restriction. Although altered placental formation may contribute to these poor outcomes, the mechanism by which selenium deficiency contributes to complications in pregnancy is poorly understood. Female C57BL/6 mice were randomly allocated to control (>190 μg/kg, n = 8) or low selenium (<50 μg/kg, n = 8) diets four weeks prior to mating and throughout gestation. Pregnant mice were sacrificed at embryonic day 18.5 followed by collection of maternal and fetal tissue. Maternal and fetal plasma thyroid hormone concentrations were analysed as was placental expression of key selenoproteins involved in thyroid metabolism and antioxidant defences. Selenium deficiency increased plasma tetraiodothyronine and triiodothyronine concentrations. This was associated with a reduction in placental expression of key selenodependent deiodinases, DIO2 and DIO3. Placental expression of selenium‐dependent antioxidants was unaffected by selenium deficiency. Selenium deficiency reduced fetal glucose concentrations leading to reduced fetal weight. Placental glycogen content was increased within the placenta as was Slc2a3 mRNA expression. This is the first study to demonstrate that selenium deficiency may reduce fetal weight through increased maternal thyroid hormone concentrations, impaired placental thyroid hormone metabolism and dysregulated placental nutrient transporter expression. This study suggests that the magnitude of selenium deficiency commonly reported in pregnant women may be sufficient to impair thyroid metabolism but not placental antioxidant concentrations.
dc.description.sponsorshipGriffith University
dc.languageEnglish
dc.publisherWiley
dc.relation.ispartofjournalJournal of Physiology
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleMaternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHofstee, P; Bartho, LA; McKeating, DR; Radenkovic, F; McEnroe, G; Fisher, JJ; Holland, OJ; Vanderlelie, JJ; Perkins, AV; Cuffe, JSM, Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth., Journal of Physiology, 2019
dcterms.dateAccepted2019-09-26
dc.date.updated2019-10-09T21:49:33Z
dc.description.versionPost-print
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2019 Physiological Society. This is the peer reviewed version of the following article: Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth, The Journal of Physiology, which has been published in final form at 10.1113/JP278473. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.hasfulltextFull Text
gro.griffith.authorCuffe, James S.
gro.griffith.authorHolland, Olivia J.
gro.griffith.authorBartho, Lucy A.
gro.griffith.authorMcKeating, Daniel R.
gro.griffith.authorFisher, Josh
gro.griffith.authorPerkins, Anthony V.
gro.griffith.authorVanderlelie, Jessica J.
gro.griffith.authorRadenkovic, Filip
gro.griffith.authorMcEnroe, Georgia D.
gro.griffith.authorHofstee, Pierre D.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record