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dc.contributor.authorGardiner, Fergus W
dc.contributor.authorMcCuaig, Ruth
dc.contributor.authorArthur, Chris
dc.contributor.authorCarins, Thomas
dc.contributor.authorMorton, Adam
dc.contributor.authorLaurie, Josephine
dc.contributor.authorNeeman, Teresa
dc.contributor.authorLim, Boon
dc.contributor.authorPeek, Michael J
dc.description.abstractBackground: To determine the prevalence and outcomes of intrahepatic cholestasis of pregnancy. Methods: A review comparing intrahepatic cholestasis of pregnancy pregnancies to all other pregnancies in three tertiary care Australian hospitals over a 36-month period. Results: There were 43,876 pregnancies. The prevalence of intrahepatic cholestasis of pregnancies (n = 319) was 0.7%. There were differences between intrahepatic cholestasis of pregnancy and non-intrahepatic cholestasis of pregnancy mothers including higher prevalence of South Asian (22.6% versus 3.1%, p < 0.001), Indigenous Australian (3.8% versus 1.8%, p < 0.05), and Asian ethnicity (8.4% versus 5.7%, p < 0.05), mothers with a body mass index >35 kg/m2 (10.6% versus 5.5%, p < 0.001), those with diabetes mellitus (25.7% versus 9.8%, p < 0.001), and those with twin births (8.7% versus 2.2%, p < 0.001). The primary clinical outcomes of intrahepatic cholestasis of pregnancy included a median gestational age at delivery of 36.4 (SE 0.09) weeks compared to 38.6 (SE 0.01) weeks (p < 0.001), a lower birth weight (3.12 (SE 0.03) versus 3.31 kg (SE 0.03), p < 0.001), and an increase in special care nursery admissions (44.5% versus 15.3%, p < 0.001). Conclusion: Treated intrahepatic cholestasis of pregnancy in the population described here had similar mortality outcomes although increased special care nursery admission as compared to the general population.
dc.publisherSage Publications
dc.relation.ispartofjournalObstetric Medicine
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsObstetrics & Gynecology
dc.subject.keywordsIntrahepatic cholestasis of pregnancy
dc.subject.keywordsliver function tests
dc.titleThe prevalence and pregnancy outcomes of intrahepatic cholestasis of pregnancy: A retrospective clinical audit review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGardiner, FW; McCuaig, R; Arthur, C; Carins, T; Morton, A; Laurie, J; Neeman, T; Lim, B; Peek, MJ, The prevalence and pregnancy outcomes of intrahepatic cholestasis of pregnancy: A retrospective clinical audit review, Obstetric Medicine, 2019, 12 (3), pp. 123-128
gro.hasfulltextNo Full Text
gro.griffith.authorCarins, Thomas

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