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dc.contributor.authorBeecher, Kate
dc.contributor.authorHafner, Louise M
dc.contributor.authorEkberg, Jenny
dc.contributor.authorSt John, James A
dc.contributor.authorChehrehasa, Fatemeh
dc.date.accessioned2019-10-10T03:14:57Z
dc.date.available2019-10-10T03:14:57Z
dc.date.issued2018
dc.identifier.issn1673-5374
dc.identifier.doi10.4103/1673-5374.238713
dc.identifier.urihttp://hdl.handle.net/10072/388247
dc.description.abstractThe olfactory receptor neurons lining the nasal cavity have a remarkable capacity to regenerate throughout life. They are replenished continuously and their axons make new connections within the olfactory bulb. However, some factors such as head trauma and skull base surgery damage the olfactory nerve which lead to olfactory dysfunction. Losing the sense of smell has considerable effects on quality of life and life-expectancy. Therefore, there is a clear need to find a treatment for olfactory dysfunction. One such potential treatment is growth factor therapy which showed promising results in the spinal cord and brain injuries. The aim of the present study was to investigate whether combined delivery of two growth factors, vascular endothelial growth factor and platelet-derived growth factor treatment can improve the olfactory neurons regeneration in mice. The degeneration of the olfactory neurons was induced by unilateral bulbectomy. The treatment group received 1.5 μg of the combined growth factors intranasally, while the control injured group received saline. Growth factor treatment significantly increased the number of immature neurons at 5 and 7 days post injury and also the number of mature olfactory neurons at 10 and 14 days post bulbectomy. Regenerating axons extended over a larger volume in the operated cavity in the treatment group compared to control group at 14 days post bulbectomy. The growth factor treatment also significantly reduced astrocytic glia scar in the operated cavity. The results indicate that the combined delivery of the growth factors has the potential to improve olfactory dysfunction.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherMedknow Publications
dc.relation.ispartofpagefrom1820
dc.relation.ispartofpageto1826
dc.relation.ispartofissue10
dc.relation.ispartofjournalNeural Regeneration Research
dc.relation.ispartofvolume13
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsCell Biology
dc.subject.keywordsNeurosciences & Neurology
dc.titleCombined VEGF/PDGF improves olfactory regeneration after unilateral bulbectomy in mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBeecher, K; Hafner, LM; Ekberg, J; St John, JA; Chehrehasa, F, Combined VEGF/PDGF improves olfactory regeneration after unilateral bulbectomy in mice, Neural Regeneration Research, 2018, 13 (10), pp. 1820-1826
dcterms.licensehttps://creativecommons.org/licenses/by-nc-sa/3.0/
dc.date.updated2019-10-10T03:11:25Z
dc.description.versionPublished
gro.rights.copyright© The Author(s) 2018. This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License (https://creativecommons.org/licenses/by-nc-sa/3.0/) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the original work is cited properly.
gro.hasfulltextFull Text
gro.griffith.authorSt John, James A.
gro.griffith.authorChehrehasa, Fatemeh
gro.griffith.authorEkberg, Jenny A.
gro.griffith.authorBeecher, Kate


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