Show simple item record

dc.contributor.authorGois, PHF
dc.contributor.authorWolley, M
dc.contributor.authorRanganathan, D
dc.contributor.authorSeguro, AC
dc.date.accessioned2019-10-10T03:47:47Z
dc.date.available2019-10-10T03:47:47Z
dc.date.issued2018
dc.identifier.issn1661-7827en_US
dc.identifier.doi10.3390/ijerph15081773en_US
dc.identifier.urihttp://hdl.handle.net/10072/388256
dc.description.abstractVitamin D (VD) is a pro-hormone essential for life in higher animals. It is present in few types of foods and is produced endogenously in the skin by a photochemical reaction. The final step of VD activation occurs in the kidneys involving a second hydroxylation reaction to generate the biologically active metabolite 1,25(OH) 2 -VD. Extrarenal 1α-hydroxylation has also been described to have an important role in autocrine and paracrine signaling. Vitamin D deficiency (VDD) has been in the spotlight as a major public healthcare issue with an estimated prevalence of more than a billion people worldwide. Among individuals with chronic kidney disease (CKD), VDD prevalence has been reported to be as high as 80%. Classically, VD plays a pivotal role in calcium and phosphorus homeostasis. Nevertheless, there is a growing body of evidence supporting the importance of VD in many vital non-skeletal biological processes such as endothelial function, renin-angiotensin-aldosterone system modulation, redox balance and innate and adaptive immunity. In individuals with CKD, VDD has been associated with albuminuria, faster progression of kidney disease and increased all-cause mortality. Recent guidelines support VD supplementation in CKD based on extrapolation from cohorts conducted in the general population. In this review, we discuss new insights on the multifactorial pathophysiology of VDD in CKD as well as how it may negatively modulate different organs and systems. We also critically review the latest evidence and controversies of VD monitoring and supplementation in CKD patients.en_US
dc.languageengen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofpagefrom1773:1en_US
dc.relation.ispartofpageto1773:16en_US
dc.relation.ispartofissue8en_US
dc.relation.ispartofjournalInternational Journal of Environmental Research and Public Healthen_US
dc.relation.ispartofvolume15en_US
dc.subject.keywordsVitamin Den_US
dc.subject.keywordsVitamin D deficiencyen_US
dc.subject.keywordschronic kidney diseaseen_US
dc.subject.keywordsproteinuriaen_US
dc.titleVitamin D deficiency in chronic kidney disease: Recent evidence and controversiesen_US
dc.typeJournal articleen_US
dcterms.bibliographicCitationGois, PHF; Wolley, M; Ranganathan, D; Seguro, AC, Vitamin D deficiency in chronic kidney disease: Recent evidence and controversies, International Journal of Environmental Research and Public Health, 2018, 15 (8), pp. 1773:1-1773:16en_US
dcterms.dateAccepted2018-08-16
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2019-10-10T03:45:14Z
dc.description.versionPublisheden_US
gro.rights.copyright© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden_US
gro.hasfulltextFull Text
gro.griffith.authorRanganathan, Dwarakanathan


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record