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dc.contributor.authorRecek, Nina
dc.contributor.authorZhou, Renwu
dc.contributor.authorZhou, Rusen
dc.contributor.authorTe'o, Valentino Setoa Junior
dc.contributor.authorSpeight, Robert E
dc.contributor.authorMozetic, Miran
dc.contributor.authorVesel, Alenka
dc.contributor.authorCvelbar, Uros
dc.contributor.authorBazaka, Kateryna
dc.contributor.authorOstrikov, Kostya Ken
dc.date.accessioned2019-10-11T00:23:49Z
dc.date.available2019-10-11T00:23:49Z
dc.date.issued2018
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/s41598-018-26227-5
dc.identifier.urihttp://hdl.handle.net/10072/388287
dc.description.abstractProduction of ethanol by the yeast Saccharomyces cerevisiae is a process of global importance. In these processes, productivities and yields are pushed to their maximum possible values leading to cellular stress. Transient and lasting enhancements in tolerance and performance have been obtained by genetic engineering, forced evolution, and exposure to moderate levels of chemical and/or physical stimuli, yet the drawbacks of these methods include cost, and multi-step, complex and lengthy treatment protocols. Here, plasma agitation is shown to rapidly induce desirable phenotypic changes in S. cerevisiae after a single treatment, resulting in improved conversion of glucose to ethanol. With a complex environment rich in energetic electrons, highly-reactive chemical species, photons, and gas flow effects, plasma treatment simultaneously mimics exposure to multiple environmental stressors. A single treatment of up to 10 minutes performed using an atmospheric pressure plasma jet was sufficient to induce changes in cell membrane structure, and increased hexokinase 2 activity and secondary metabolite production. These results suggest that plasma treatment is a promising strategy that can contribute to improving metabolic activity in industrial microbial strains, and thus the practicality and economics of industrial fermentations.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofpagefrom8252:1
dc.relation.ispartofpageto8252:13
dc.relation.ispartofissue1
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume8
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3101
dc.subject.keywordsScience & Technology
dc.subject.keywordsMultidisciplinary Sciences
dc.subject.keywordsATMOSPHERIC-PRESSURE PLASMA
dc.subject.keywordsETHANOL STRESS RESPONSES
dc.titleImproved fermentation efficiency of S. cerevisiae by changing glycolytic metabolic pathways with plasma agitation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRecek, N; Zhou, R; Zhou, R; Te'o, VSJ; Speight, RE; Mozetic, M; Vesel, A; Cvelbar, U; Bazaka, K; Ostrikov, KK, Improved fermentation efficiency of S. cerevisiae by changing glycolytic metabolic pathways with plasma agitation, Scientific Reports, 2018, 8 (1), pp. 8252:1-8252:13
dcterms.dateAccepted2018-04-18
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-10-11T00:03:36Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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gro.griffith.authorOstrikov, Ken


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