Show simple item record

dc.contributor.authorIrani, Soussan
dc.contributor.authorDehghan, Arash
dc.date.accessioned2019-10-11T05:46:37Z
dc.date.available2019-10-11T05:46:37Z
dc.date.issued2018
dc.identifier.issn2231-0762
dc.identifier.doi10.4103/jispcd.JISPCD_408_17
dc.identifier.urihttp://hdl.handle.net/10072/388314
dc.description.abstractObjectives: Ninety percent of head and neck cancers are squamous cell carcinoma which develops in the oral cavity. Metastasis is the main causative factor for death in 90% of all cancer-related deaths and begins with the invasion of tumor cells through the walls of small blood vessels or lymph vessels. A growing body of evidence has shown that vasculogenic mimicry (VM) facilitates tumor growth and cancer metastasis. The current study aimed to present the role of vascular endothelial (VE)-cadherin, CD44, and vimentin in inducing VM and epithelial-mesenchymal transition (EMT) and to identify the cancer stem cell (CSC) niche in different grades of oral squamous cell carcinoma (OSCC). Materials and Methods: A total of 63 OSCC samples (21 samples each grade) were collected from the archive of Pathology Department of Besat educational hospital, Hamadan, Iran, from 2000 to 2015. VE-cadherin, CD44, and vimentin/periodic acid-Schiff (PAS) double-staining were used to validate VM. VM was identified by the detection of PAS-positive loops surrounded by tumor cells. Chi-square test was used to examine the differences between the variables. Significant level was set at 0.05. Pearson's correlation was used to assess the co-localization of the markers. Results: There were statistically significant differences between tumor grade and the expression levels of VE-cadherin, CD44, and vimentin (P = 0.000). In addition, significant differences were found between tumor grade and microvessel density (P = 0.000) and between tumor grade and VM (P = 0.000). Conclusion: Our results may disclose a definite relationship between VE-cadherin, CD44 and vimentin expression levels, VM formation, EMT, CSCs, and microvessel count in OSCC samples. For this reason, it is suggested that VE-cadherin, CD44, and vimentin are related to angiogenesis and VM formation in OSCC, therefore, in tumor progression and metastasis. Recently, antitumor angiogenic therapies have been challenged. The presence of VM may explain the failure of antiangiogenic treatments.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMEDKNOW PUBLICATIONS & MEDIA PVT LTD
dc.relation.ispartofpagefrom110
dc.relation.ispartofpageto117
dc.relation.ispartofissue2
dc.relation.ispartofjournalJournal of International Society of Preventive and Community Dentistry
dc.relation.ispartofvolume8
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchcode3203
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsDentistry, Oral Surgery & Medicine
dc.subject.keywordsCD44
dc.subject.keywordsoral squamous cell carcinoma
dc.titleThe Expression and Functional Significance of Vascular Endothelial-Cadherin, CD44, and Vimentin in Oral Squamous Cell Carcinoma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationIrani, S; Dehghan, A, The Expression and Functional Significance of Vascular Endothelial-Cadherin, CD44, and Vimentin in Oral Squamous Cell Carcinoma, Journal of International Society of Preventive and Community Dentistry, 2018, 8 (2), pp. 110-117
dcterms.dateAccepted2018-01-15
dcterms.licensehttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.date.updated2019-10-11T05:43:38Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. If you alter, transform, or build upon this work, you may distribute the resulting work only under a licence identical to this one.
gro.hasfulltextFull Text
gro.griffith.authorIrani, Soussan


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record