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dc.contributor.authorIqbal, Sameera
dc.contributor.authorFard, Mina Ghanimi
dc.contributor.authorEverest-Dass, Arun
dc.contributor.authorPacker, Nicolle H
dc.contributor.authorParker, Lindsay M
dc.date.accessioned2019-10-14T01:01:37Z
dc.date.available2019-10-14T01:01:37Z
dc.date.issued2019
dc.identifier.issn0300-5127
dc.identifier.doi10.1042/BST20180330
dc.identifier.urihttp://hdl.handle.net/10072/388329
dc.description.abstractGlycosylation, the enzymatic process by which glycans are attached to proteins and lipids, is the most abundant and functionally important type of post-translational modification associated with brain development, neurodegenerative disorders, psychopathologies and brain cancers. Glycan structures are diverse and complex; however, they have been detected and targeted in the central nervous system (CNS) by various immunohistochemical detection methods using glycan-binding proteins such as anti-glycan antibodies or lectins and/or characterized with analytical techniques such as chromatography and mass spectrometry. The glycan structures on glycoproteins and glycolipids expressed in neural stem cells play key roles in neural development, biological processes and CNS maintenance, such as cell adhesion, signal transduction, molecular trafficking and differentiation. This brief review will highlight some of the important findings on differential glycan expression across stages of CNS cell differentiation and in pathological disorders and diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis, schizophrenia and brain cancer.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPortland Press Ltd.
dc.relation.ispartofpagefrom89
dc.relation.ispartofpageto100
dc.relation.ispartofissue1
dc.relation.ispartofjournalBiochemical Society Transactions
dc.relation.ispartofvolume47
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchMedical Biochemistry and Metabolomics
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1101
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsBiochemistry & Molecular Biology
dc.subject.keywordsSYMPATHETIC PREGANGLIONIC NEURONS
dc.subject.keywordsPROTEIN GLYCOSYLATION ANALYSIS
dc.titleUnderstanding cellular glycan surfaces in the central nervous system
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationIqbal, S; Fard, MG; Everest-Dass, A; Packer, NH; Parker, LM, Understanding cellular glycan surfaces in the central nervous system, Biochemical Society Transactions, 2019, 47 (1), pp. 89-100
dcterms.dateAccepted2018-11-06
dc.date.updated2019-10-14T00:57:42Z
gro.hasfulltextNo Full Text
gro.griffith.authorEverest-Dass, Arun
gro.griffith.authorPacker, Nicki


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